Adeela Syed
Biography
Adeela Syed, Ph.D., is Associate Project Scientist and Manager of the Optical Biology Core Facility at the University of California, Irvine. Over 15 years, she has expanded the core from 2 confocal microscopes to a comprehensive advanced imaging suite including 4 confocals, 1 mesoscale light-sheet microscope, 1 super-resolution microscope, and 1 automated slide scanner, securing over $1 million in institutional funds and co-authoring a successful NIH S10 proposal for over $600,000 in external funding. She has trained more than 1,500 researchers since 2011 on confocal, super-resolution, and light-sheet microscopy platforms, supporting research across multiple departments.
Syed founded and co-leads the UC-wide Imaging Core Working Group, a system-wide initiative connecting imaging core personnel from all 10 UC campuses to share best practices and operational strategies. She co-organizes the Advanced Imaging Methods (AIM) Workshop at UC Berkeley and was co-organizer of the inaugural FLAIR (Fluorescence Advanced Imaging Research) Workshop, which merged the UCI Laboratory Fluorescence Dynamics and UC Berkeley AIM meetings into the largest west coast advanced fluorescence imaging meeting with over 100 attendees. She was selected as an invited presenter at the Global BioImaging Exchange of Experience Conference and participated in the Global BioImaging Facility Management Course in Montreal, Canada.
Syed's research background includes work on Huntington's Disease mechanisms, HDAC inhibitors, and Wnt and BMP morphogen regulation during her postdoctoral and project scientist positions at UC Irvine. She received a Ph.D. in Biochemistry from the University of California, Los Angeles.
Return to topEducation
- Ph.D. in Biochemistry, University of California, Los Angeles
- B.S. in Biology, University of California, Irvine
- B.S. in Chemistry, University of California, Irvine
Areas of Expertise
- Advanced Fluorescence Microscopy
- Confocal Imaging Techniques
- Super-Resolution Microscopy Platforms
- Light-Sheet Microscopy Applications
- Huntington's Disease Mechanisms
- Wnt Signaling Pathway Regulation
- Electrochemical Lipolysis Methods
Recent Publications
- Park A, Pham TT, Heidari AE, Hong EM, Steward E, Chen LY, Qu Y, Dunn BS, Seo SH, Patel U, Dilley K, Hakimi AA, Syed A, Kim S, Hill MG, You JS, Wong BJF, “Electrochemical Lipolysis Induces Adipocyte Death and Fat Necrosis: In Vivo Pilot Study in Pigs” (opens in new tab), Plastic and Reconstructive Surgery, vol. 153, pp. 334-347, 2023.
- Heidari AE, Hong EM, Park A, Pham TT, Steward E, Chen LY, Qu Y, Dunn BS, Seo SH, Patel U, Dilley K, Hakimi AA, Syed A, Kim S, Hill MG, You JS, Wong BJF, “Exploring feedback-controlled versus open-circuit electrochemical lipolysis in ex vivo and in vivo porcine fat: A feasibility study” (opens in new tab), Lasers in Surgery and Medicine, vol. 54, pp. 157-169, 2022.
- Chongtham A, Bornemann DJ, Barbaro BA, Lukacsovich T, Agrawal N, Syed A, Worthge S, Purcell J, Burke J, Chin TM, Marsh JL, “Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT” (opens in new tab), Human Molecular Genetics, vol. 29, pp. 674-688, 2020.
- Syed A, Lukacsovich T, Pomeroy M, Bardwell AJ, Decker GT, Waymire KG, Purcell J, Huang W, Gui J, Padilla EM, Park C, Paula A, Pham TBT, Rodriguez Y, Wei S, Worthge S, Zebarjedi R, Zhang B, Bardwell L, Marsh JL, et al., “Miles to go (mtgo) encodes FNDC3 proteins that interact with CCT3 and are required for NMJ branching and growth in Drosophila” (opens in new tab), Developmental Biology, vol. 445, pp. 37-53, 2019.
- Chongtham A, Barbaro B, Filip T, Syed A, Huang W, Smith M, Marsh JL, “Non-mammalian Models of Huntington's Disease” (opens in new tab), Methods in Molecular Biology, vol. 1780, pp. 75-96, 2018.
- Song W, Smith MR, Syed A, Lukacsovich T, Barbaro BA, Purcell J, Bornemann DJ, Burke J, Marsh JL, “Morphometric Analysis of Huntington's Disease Neurodegeneration in Drosophila” (opens in new tab), Methods in Molecular Biology, vol. 1017, pp. 41-57, 2013.
- Iron D, Syed A, Theisen H, Lukacsovich T, “The role of feedback in the formation of morphogen territories” (opens in new tab), Mathematical Biosciences and Engineering, vol. 5, pp. 277-298, 2008.
- Wang JT, Syed A, Gralla JD, “Multiple pathways to bypass the enhancer requirement of sigma 54 RNA polymerase”, PNAS, 1997.
- Syed A, Gralla JD, “Isolation and properties of enhancer by-pass mutants of sigma 54” (opens in new tab), Molecular Microbiology, vol. 23, pp. 987-995, 1997.
Most Cited Publications
- Theisen H, Purcell J, Bennett M, Kansagara D, Syed A, Marsh JL, “dishevelled is required during wingless signaling to establish both cell polarity and cell identity”, Development, vol. 120, pp. 347-360, 1994.
- Jia H, Pallos J, Jacques V, Lau A, Tang B, Cooper A, Syed A, Purcell J, “HDAC inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease” (opens in new tab), Neurobiology of Disease, vol. 46, pp. 351-361, 2012.
- Smith M.R., Syed A., Lukacsovich T., Purcell J., Barbaro B.A., Worthge S.A., Wei S.R., Pollio G., Magnoni L., Scali C., Massai L., Franceschini D., Camarri M., Gianfriddo M., Diodato E., Thomas R., Gokce O., Tabrizi S.J., Caricasole A., Landwehrmeyer B., et al., “A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease” (opens in new tab), Human Molecular Genetics, vol. 23, pp. 2995-3007, 2014.
- Atcha FA, Syed A, Wu B, Hoverter NP, Yokoyama NN, Ting JHT, Munguia JE, Mangalam HJ, Marsh JL, Waterman ML, “A Unique DNA Binding Domain Converts T-Cell Factors into Strong Wnt Effectors” (opens in new tab), Molecular and Cellular Biology, vol. 27, pp. 8352-8363, 2007.
- Wang JT, Syed A, Hsieh M, Gralla JD, “Converting E. coli RNA polymerase into an enhancer responsive enzyme” (opens in new tab), Science, vol. 270, pp. 992-994, 1995.
- Wang J.T., Syed A., Gralla J.D., “Multiple pathways to bypass the enhancer requirement of sigma 54 RNA polymerase: Roles for DNA and protein determinants” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 94, pp. 9538-9543, 1997.
- Sameni S, Syed A, Marsh JL, Digman M, “The Phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease” (opens in new tab), Scientific Reports, vol. 6, 2016.
- Najdi R, Syed A, Arce L, Theisen H, Ting JHT, Atcha F, Nguyen A, Martinez M, Holcombe RF, Edwards RA, Marsh JL, Waterman ML, “A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer” (opens in new tab), Oncogene, vol. 28, pp. 4133-4146, 2009.
- Theisen H, Syed A, Nguyen BT, Lukacsovich T, Purcell J, “Wingless Directly Represses DPP Morphogen Expression via an Armadillo/TCF/Brinker Complex” (opens in new tab), PLoS ONE, vol. 2, 2007.
- Syed A, Gralla JD, “Identification of an N-Terminal Region of Sigma 54 Required for Enhancer Responsiveness” (opens in new tab), Journal of Bacteriology, vol. 180, pp. 5619-5625, 1998.
Contact Information
Email: adeelas@uci.edu
Phone: (949) 824-2597
Address: 4109 McGaugh Hall
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Last updated on 4/23/2026.