Aydin Eresen

Assistant Researcher, Dept. of Radiological Sciences, University of California, Irvine

Biography

Aydin Eresen, Ph.D., is an Assistant Researcher in the Department of Radiological Sciences at the University of California, Irvine. Eresen's research focuses on developing and applying advanced MRI techniques and machine learning methods to monitor and predict therapeutic responses in cancer treatment, particularly for hepatocellular carcinoma and pancreatic ductal adenocarcinoma. His work integrates medical imaging with immunotherapy approaches, including natural killer cell-based treatments and dendritic cell vaccines, often in combination with interventional procedures such as irreversible electroporation ablation.

Eresen has served as principal investigator on grants from the Society of Interventional Radiology Foundation and the UCI Chao Family Comprehensive Cancer Center, and has submitted multiple NIH grant applications as principal investigator. He has also contributed as co-investigator on an active NIH R01 grant focused on MRI-guided dendritic cell vaccination strategies for pancreatic cancer. His research has resulted in over 40 peer-reviewed journal publications and numerous conference presentations at venues including the Society of Interventional Radiology and the International Society for Magnetic Resonance in Medicine.

Eresen received his Ph.D. in Electrical Engineering from Texas A&M University in 2018, where his dissertation focused on detection of MRI biomarkers for Golden Retriever Duchenne muscular dystrophy. He serves on the editorial review boards of Cancer Control, Frontiers in Artificial Intelligence, and Academic Radiology, and has served as a reviewer for over 100 scientific journals. At UC Irvine, he has co-mentored numerous undergraduate and graduate students in biological sciences and biomedical engineering.

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Education

Ph.D. in Electrical Engineering, Texas A&M University, 2018
M.S. in Electrical and Electronics Engineering, TOBB University of Economics and Technology, 2010
B.S. in Electrical and Electronics Engineering, Pamukkale University, 2007

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Distinctions

Texas A&M University Electrical Engineering Departmental Scholarship, 2013
Ph.D. Scholarship by Ministry of National Education, Turkey, 2012-2017
M.S. Fellowship by The Scientific and Technological Research Council of Turkey, 2008-2010
Tomography Outstanding Reviewer Award, 2023
Academic Radiology Outstanding Reviewer, 2022
Summa cum laude in M.S. and B.S., 2007-2010

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Areas of Expertise

Translational Medical Imaging
Radiomics Texture Analysis
Irreversible Electroporation Ablation
Duchenne Muscular Dystrophy Biomarkers
Natural Killer Cell Immunotherapy
Hepatocellular Carcinoma Treatment
Pancreatic Cancer Dendritic Vaccination

Recent Publications

L. Limfueco, A. Eresen, Z. Zhang, G. Yu, Q. Hou, Z. Zhang, “Hepatocellular Carcinoma Therapeutic Response to Systemic Delivery of Engineered Natural Killer Cells in Combination Therapy with Sorafenib”, Journal of Vascular and Interventional Radiology, vol. 36, no. 3, Supplement, pp. S61-62, 2025.
A. Eresen, Z. Zhang, G. Yu, A. Zhang, Q. Hou, V. Yaghmai, “Sorafenib plus Memory Like Natural Killer Cell Immunochemotherapy in Hepatocellular Carcinoma and Assessment of Local Response Using Machine Learning”, Journal of Vascular and Interventional Radiology, vol. 36, no. 3, Supplement, pp. S46, 2025.
L. Limfueco, A. Eresen, Z. Zhang, G. Yu, Q. Hou, Z. Zhang, “Hepatocellular Carcinoma Therapeutic Response to Systemic Delivery of Engineered Natural Killer Cells in Combination Therapy with Sorafenib”, 2025. Presented at SIR 2025.
A. Eresen, Z. Zhang, G. Yu, A. Zhang, Q. Hou, V. Yaghmai, “Sorafenib plus Memory Like Natural Killer Cell Immunochemotherapy in Hepatocellular Carcinoma and Assessment of Local Response Using Machine Learning”, 2025. Presented at SIR 2025.
A. Eresen, Y. Pang, Z. Zhang, Q. Hou, Z. Chen, G. Yu, Y. Wang, V. Yaghmai, Z. Zhang, “Sorafenib plus Memory Like Natural Killer Cell Combination Therapy in Hepatocellular Carcinoma”, American Journal of Cancer Research, vol. 14, no. 1, pp. 344-354, 2024.
A. Eresen, Z. Zhang, G. Yu, Q. Hou, Z. Chen, Z. Yu, V. Yaghmai, Z. Zhang, “Sorafenib plus transcatheter intraarterial memory-like natural killer cell immunochemotherapy boosts therapeutic response in hepatocellular carcinoma” (opens in new tab), BMC Cancer, vol. 24, no. 1, pp. 1215, 2024.
Z. Zhang, A. Eresen, G. Yu, K. Liu, Q. Hou, V. Yaghmai, Z. Zhang, “Transcatheter Intraarterial Delivery of Combination Therapy for Hepatocellular Carcinoma”, Journal of Vascular and Interventional Radiology, vol. 35, no. 3, pp. S199, 2024.
K. Liu, G. Yu, Z. Zhang, Q. Hou, V. Yaghmai, Z. Zhang, A. Eresen, “Investigation of Natural Killer Cell Delivery in Hepatocellular Carcinoma Treatment with Magnetic Resonance Imaging Radiomics”, Journal of Vascular and Interventional Radiology, vol. 35, no. 3, pp. S92, 2024.
G. Yu, A. Eresen, Z. Zhang, K. Liu, Q. Hou, V. Yaghmai, Z. Zhang, “Evaluating Hepatocellular Carcinoma Combination Therapy of Sorafenib and Transcatheter Primed Natural Killer Cell Delivery Using MRI Radiomics Methods”, Journal of Vascular and Interventional Radiology, vol. 35, no. 3, pp. S143-144, 2024.
A. Eresen, Z. Zhang, G. Yu, Q. Hou, N. Abi-Jaoudeh, V. Yaghmai, Z. Zhang, “Improving Therapeutic Response Against Hepatocellular Carcinoma with Cytokine-Activated Natural Killer Cells via Transcatheter Intraarterial Administration”, Journal of Vascular and Interventional Radiology, vol. 35, no. 3, pp. S152, 2024.
K. Liu, G. Yu, Z. Zhang, Q. Hou, V. Yaghmai, Z. Zhang, A. Eresen, “Investigation of Natural Killer Cell Delivery in Hepatocellular Carcinoma Treatment with Magnetic Resonance Imaging Radiomics”, 2024. Presented at SIR 2024.
G. Yu, A. Eresen, Z. Zhang, K. Liu, Q. Hou, V. Yaghmai, Z. Zhang, “Evaluating Hepatocellular Carcinoma Combination Therapy of Sorafenib and Transcatheter Primed Natural Killer Cell Delivery Using MRI Radiomics Methods”, 2024. Presented at SIR 2024.
A. Eresen, Z. Zhang, G. Yu, Q. Hou, N. Abi-Jaoudeh, V. Yaghmai, Z. Zhang, “Improving Therapeutic Response Against Hepatocellular Carcinoma with Cytokine-Activated Natural Killer Cells via Transcatheter Intraarterial Administration”, 2024. Presented at SIR 2024.
A. Eresen, Z. Zhang, Z. Yu, N. Abi-Jaoudeh, F. Nouizi, V. Yaghmai, Z. Zhang, “MRI monitoring transcatheter intraportal vein delivery of clinically applicable-magnetic labelled natural killer cells for liver tumor adoptive immunotherapy”, Journal of Vascular and Interventional Radiology, vol. 34, no. 3, pp. S112, 2023.
K. Liu, Z. Zhang, Q. Hou, Y. Pang, F. Nouzi, V. Yaghmai, Z. Zhang, A. Eresen, “Differentiation of irreversible electroporation regions in normal and tumor tissues using MRI textures”, Journal of Vascular and Interventional Radiology, vol. 34, no. 3, pp. S25, 2023.
F. Nouizi, A. Eresen, Z. Zhang, V. Yaghmai, G. Gulsen, Z. Zhang, “Longitudinal monitoring of irreversible electroporation outcomes using hybrid functional/structural variations of HCC microenvironment”, Journal of Vascular and Interventional Radiology, vol. 34, no. 3, pp. S7, 2023.
Z. Yu, Z. Zhang, J. Tan, Q. Hou, F. Nouizi, V. Yaghmai, Z. Zhang, A. Eresen, “Quantitative MRI texture analysis for evaluating treatment response following irreversible electroporation ablation in hepatocellular carcinoma”, Journal of Vascular and Interventional Radiology, vol. 34, no. 3, pp. S82, 2023.
Z. Zhang, A. Eresen, Z. Chen, Z. Yu, N. Abi-Jaoudeh, V. Yaghmai, Z. Zhang, “MRI monitoring transcatheter intraarterial delivery of clinical magnetically labeled natural killer adoptive immunotherapy”, Journal of Vascular and Interventional Radiology, vol. 34, no. 3, pp. S109, 2023.
Z. Zhang, A. Eresen, Z. Chen, Z. Yu, N. Abi-Jaoudeh, V. Yaghmai, Z. Zhang, “MRI Monitoring Transcatheter Intraarterial Delivery of Clinical Magnetically-Labeled Natural Killer Adoptive Immunotherapy”, 2023. Presented at SIR 2023.
Z. Yu, Z. Zhang, J. Tan, Q. Hou, F. Nouzi, V. Yaghmai, Z. Zhang, A. Eresen, “Quantitative MRI texture analysis for evaluating treatment response following Irreversible electroporation ablation in hepatocellular carcinoma”, 2023. Presented at SIR 2023.

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Most Cited Publications

A. Eresen, N. Imamoglu, M.O. Efe, “Autonomous quadrotor flight with vision-based obstacle avoidance in virtual environment” (opens in new tab), Expert Systems with Applications, vol. 39, pp. 894-905, 2012.
A. Eresen, J. Yang, N. Abi-Jaoudeh, V. Yaghmai, Z. Zhang, “Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve immunotherapy: preclinical feasibility studies in a mouse model of pancreatic cancer” (opens in new tab), Journal of Vascular and Interventional Radiology, vol. 33, no. 6, pp. S161, 2022.
Y. Li, A. Eresen, J. Yang, J. Shangguan, A. B. Benson III, V. Yaghmai, Z. Zhang, “Preoperative Prediction of Perineural Invasion and KRAS Mutation in Colon Cancer using Machine Learning” (opens in new tab), Journal of Cancer Research and Clinical Oncology, vol. 146, pp. 3165-3174, 2020.
A. Eresen, Y. Li, Y. Lu, J. Yang, J. Shangguan, Y. Velichko, V. Yaghmai, AB. Benson III, Z. Zhang, “Preoperative assessment of lymph node metastasis in Colon Cancer patients using machine learning: a pilot study” (opens in new tab), Cancer Imaging, vol. 20, no. 30, 2020.
A. Eresen, J. Yang, J. Shangguan, S. Hu, C. Sun, Y. Velichko, V. Yaghmai, Z. Zhang, “MRI radiomics for early prediction of response to vaccine therapy in a transgenic mouse model of pancreatic ductal adenocarcinoma” (opens in new tab), Journal of Translational Medicine, vol. 18, no. 61, 2020.
R.E. Osgoueia, A.M. Ozbayoglu, E.M. Ozbayoglu, Y. Ertan, A. Eresen, “Pressure drop estimation in horizontal annuli for liquid–gas 2 phase flow: Comparison of mechanistic models and computational intelligence techniques” (opens in new tab), Computers and Fluids, vol. 112, pp. 108-115, 2015.
L. Alic, J.F. Griffin IV, A. Eresen, J.N. Kornegay, J.X. Ji, “Using MRI to quantify skeletal muscle pathology in Duchene muscular dystrophy: A systematic review” (opens in new tab), Muscle and Nerve, vol. 64, no. 1, pp. 8-22, 2021.
A. Eresen, J. Yang, J. Shangguan, A. B. Benson III, V. Yaghmai, Z. Zhang, “Detection of immunotherapeutic response in a transgenic mouse model of pancreatic ductal adenocarcinoma using multiparametric MRI radiomics: a preliminary investigation” (opens in new tab), Academic Radiology, vol. S1076-6332(20)30238-5, pp. e147-e154, 2020.
Eresen A., Alic L., Birch S.M., Friedeck W., Griffin J.F., Kornegay J.N., Jim X. J.I., “Texture as an imaging biomarker for disease severity in golden retriever muscular dystrophy” (opens in new tab), Muscle and Nerve, vol. 59, pp. 380-386, 2019.
A. Eresen, SM Birch, L. Alic, J. F. Griffin IV, J. N. Kornegay, J. X. Ji, “New similarity metric for registration of MRI to histology: golden retriever muscular dystrophy imaging” (opens in new tab), IEEE Transactions of Biomedical Engineering, vol. 66, no. 5, pp. 1222-1230, 2019.

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Contact Information

Email: aeresen@uci.edu

Phone: (949) 824-1283

Address: 839 Health Sciences Road, Sprague Hall 222, Irvine, CA 92617, Irvine, CA 92697

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This profile was created with the help of AI.

Last updated on 2/17/2026.