Ahmed Mohyeldin
Biography
Ahmed Mohyeldin, M.D., Ph.D., is Assistant Professor in the Department of Neurosurgery at UC Irvine School of Medicine, where he also serves as Team Leader of the Neuro-Oncology Disease Oriented program at the Chao Cancer Center and Co-Director of the Endoscopic Skull Base Program and Pituitary Center. He received his Ph.D. in Neuroscience from the Uniformed Services University of the Health Sciences and his M.D. from George Washington University School of Medicine. Following neurosurgery residency at The Ohio State University Wexner Medical Center, he completed dual fellowships in skull base and endoscopic cranial surgery at Ohio State and Stanford University Medical Center. Before pursuing medicine, Mohyeldin was a professional soccer player, drafted 8th overall in the first round by the Atlanta Silverbacks of the United States Soccer League.
Mohyeldin's research focuses on the molecular biology of brain tumors and skull base neoplasms, with particular emphasis on glioblastoma stem cells and pituitary adenomas. His laboratory work has examined cancer stem cell biology, tumor metabolism, and the role of transcription factors in tumor invasion and progression. He has published over 70 peer-reviewed articles and contributed 11 book chapters to neurosurgical texts. His clinical research has advanced understanding of pituitary adenoma invasion patterns, particularly regarding cavernous sinus involvement and its implications for surgical outcomes in acromegaly and Cushing's disease.
Mohyeldin received the Fred Gentili Clinical Excellence Award from the North American Skull Base Society in 2022 and the Rhoton Award for Best Anatomical Paper in 2023. He has been awarded multiple research grants, including a Maryland Stem Cell Postdoctoral Research Fellowship and a NASBS Career Development Award. He serves on the NASBS Research Committee and Grant Review Committee, and is an ad hoc reviewer for multiple neurosurgical journals. Mohyeldin is actively involved in clinical trials investigating novel treatments for glioblastoma and brain metastases, serving as principal investigator on studies examining surgical management of chronic subdural hematomas and as co-investigator on trials evaluating immunotherapy and radiosurgery approaches.
Return to topEducation
- B.S. in Neuroscience and Behavioral Biology, Emory University, 1999
- Ph.D. in Neuroscience, Uniformed Services University of The Health Sciences, 2004
- M.D., George Washington University School of Medicine, 2011
Distinctions
- Rhoton Award for Best Anatomical Paper, NASBS, 2023
- The Fred Gentili Clinical Excellence Award, NASBS, 2022
- NASBS Career Development Award, 2025
- Arthur Ashe Award of Distinction, 1999
- AANS Medical Student Award, 2007
- National Academic All-American Award, 1998-1999
- NCAA Foundation Leadership Conference Award of Distinction, 1999
- NCAA Postgraduate Scholarship Award, 1999
- Maryland Stem Cell Postdoctoral Research Fellowship, 2009-2011
- The Ohio State Neurosurgical Society Resident Talk Award (1st Place), 2018
Areas of Expertise
- Skull Base Neurosurgery
- Pituitary Neuroendocrine Tumor Biology
- Glioblastoma Stem Cell Metabolism
- Hypoxia-Inducible Factor Signaling
- Methylation Profiling Pituitary Adenomas
- Spatial Transcriptomics Brain Metastases
- Circulating Tumor DNA Detection
Recent Publications
- Fote G, Shahin H, Brown NJ, Falcone J, Lopez A, Kuan EC, Hsu FPK, Oh MY, Mohyeldin A, “Reappraisal of the Previously Described False Localizing Sign at C1-2 in Cases of Spontaneous Intracranial Hypotension” (opens in new tab), Operative Neurosurgery (Hagerstown), vol. 28, no. 4, pp. 468-477, 2025.
- Mohyeldin A, Nunez MA, Xu Y, Fernandez-Miranda JC, “Resection of corticotroph microadenomas invading the medial wall of the cavernous sinus in two cases of a primary and recurrent case of Cushing's disease” (opens in new tab), Neurosurgical Focus Video, vol. 9, no. 1, pp. V2, 2023.
- Xu Y, Mohyeldin A, Lee CK, Nunez MA, Mao Y, Cohen-Gadol AA, Fernandez-Miranda JC, “Endoscopic Endonasal Approach to the Ventral Petroclival Fissure: Anatomical Findings and Surgical Techniques” (opens in new tab), Journal of Neurological Surgery Part B Skull Base, vol. 85, pp. 420-430, 2023.
- Nunez MA, Mohyeldin A, Marotta DA, Vigo V, Asmaro K, Xu Y, Cohen-Gadol AA, Fernandez-Miranda JC, “Reappraisal of the anatomy of the frontotemporal branches of the facial nerve” (opens in new tab), Journal of Neurosurgery, vol. 139, no. 4, pp. 1160-1168, 2023.
- Gendreau JL, Kuo CC, Patel NA, Brown NJ, Pennington Z, Bui NE, Reardon T, Lien BV, Prevedello DM, Kuan EC, Hsu FPK, Mohyeldin A, “Staged Resection of Difficult-to-Treat Intracranial Meningiomas: A Systematic Review of the Indications, Surgical Approaches, and Postoperative Outcomes” (opens in new tab), Journal of Neurological Surgery Part B Skull Base, vol. 85, no. 2, pp. 131-144, 2023.
- Xu Y, Mohyeldin A, Asmaro KP, Nunez MA, Doniz-Gonzalez A, Vigo V, Cohen-Gadol AA, Fernandez-Miranda JC, “Intracranial Breakthrough Through Cavernous Sinus Compartments: Anatomic Study and Implications for Pituitary Adenoma Surgery” (opens in new tab), Oper Neurosurg (Hagerstown), vol. 23, no. 2, pp. 115-124, 2022.
- Mohyeldin A, Katznelson LJ, Hoffman AR, Asmaro K, Ahmadian SS, Eltobgy MM, Nayak JV, Patel ZM, Hwang PH, Fernandez-Miranda JC, “Prospective intraoperative and histologic evaluation of cavernous sinus medial wall invasion by pituitary adenomas and its implications for acromegaly remission outcomes” (opens in new tab), Scientific Reports, vol. 12, no. 1, pp. 9919, 2022.
- Xu Y, Mohyeldin A, Nunez MA, Doniz-Gonzalez A, Vigo V, Cohen-Gadol AA, Fernandez-Miranda JC, “Microvascular anatomy of the medial temporal region” (opens in new tab), Journal of Neurosurgery, vol. 137, no. 3, pp. 747-759, 2022.
- Son E.Y., Mohyeldin A., Men C., Pendharkar A., Fernandez-Miranda J.C., Kossler A.L., “Primary central nervous system amyloidoma involving cranial nerves V and VII: A case report and literature review” (opens in new tab), Interdisciplinary Neurosurgery Advanced Techniques and Case Management, vol. 28, 2022.
- Xu Y, Nunez MA, Mohyeldin A, Fernandez-Miranda JC, Cohen-Gadol AA, “Endoscopic Anatomy of the Zygomatic Nerve: Implications for the Endoscopic Transmaxillary Approach” (opens in new tab), Journal of Neurological Surgery Part B Skull Base, vol. 83, no. 4, pp. 430-434, 2021.
- London NR Jr, Mohyeldin A, Silveira-Bertazzo G, Prevedello DM, Carrau RL, “Video Demonstration of a Tunneled Temporoparietal Fascia Flap: How I Do It” (opens in new tab), Laryngoscope, vol. 131, no. 4, pp. E1088-E1093, 2021.
- Xu Y, Mohyeldin A, Doniz-Gonzalez A, Vigo V, Pastor-Escartin F, Meng L, Cohen-Gadol AA, Fernandez-Miranda JC, “Microsurgical anatomy of the lateral posterior choroidal artery: implications for intraventricular surgery involving the choroid plexus” (opens in new tab), Journal of Neurosurgery, vol. 135, no. 5, pp. 1534-1549, 2021.
- London NR Jr, Mohyeldin A, Carrau RL, Prevedello DM, “Endoscopic Endonasal Odontoidectomy with Nasopharyngeal Flap Reconstruction” (opens in new tab), J Neurol Surg B Skull Base, vol. 82, no. Suppl 1, pp. S12-S13, 2021.
Most Cited Publications
- Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A, “Oxygen in stem cell biology: a critical component of the stem cell niche” (opens in new tab), Cell Stem Cell, vol. 7, no. 2, pp. 150-61, 2010.
- McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A, “Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells” (opens in new tab), Journal of Biological Chemistry, vol. 283, no. 33, pp. 22700-8, 2008.
- Hsu W, Mohyeldin A, Shah SR, ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL, Quiñones-Hinojosa A, “Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target” (opens in new tab), Journal of Neurosurgery, vol. 115, no. 4, pp. 760-9, 2011.
- Mohyeldin A, Lu H, Dalgard C, Lai SY, Cohen N, Acs G, Verma A, “Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma” (opens in new tab), Neoplasia, vol. 7, no. 5, pp. 537-43, 2005.
- Dalgard CL, Lu H, Mohyeldin A, Verma A, “Endogenous 2-oxoacids differentially regulate expression of oxygen sensors” (opens in new tab), Biochemical Journal, vol. 380, no. Pt 2, pp. 419-24, 2004.
- Momin EN, Mohyeldin A, Zaidi HA, Vela G, Quiñones-Hinojosa A, “Mesenchymal stem cells: new approaches for the treatment of neurological diseases” (opens in new tab), Current Stem Cell Research and Therapy, vol. 5, no. 4, pp. 326-44, 2010.
- Awad AJ, Mohyeldin A, El-Sayed IH, Aghi MK, “Sinonasal morbidity following endoscopic endonasal skull base surgery” (opens in new tab), Clinical Neurology and Neurosurgery, vol. 130, pp. 162-7, 2015.
- Mohyeldin A, Chiocca EA, “Gene and viral therapy for glioblastoma: a review of clinical trials and future directions” (opens in new tab), Cancer Journal, vol. 18, no. 1, pp. 82-8, 2012.
- Mohyeldin A, Dalgard CL, Lu H, Mcfate T, Tait AS, Patel VC, Wong K, Rushing E, Roy S, Acs G, Verma A, “Survival and invasiveness of astrocytomas promoted by erythropoietin” (opens in new tab), Journal of Neurosurgery, vol. 106, no. 2, pp. 338-50, 2007.
- Mohyeldin A, Lonser RR, Elder JB, “Real-time magnetic resonance imaging-guided frameless stereotactic brain biopsy: technical note” (opens in new tab), Journal of Neurosurgery, vol. 124, no. 4, pp. 1039-46, 2016.
Contact Information
Email: ahmed.mohyeldin@uci.edu
Phone: (714) 456-6966
Address: 101 The City Drive, S, Bldg. 63 Manchester Pavilion, Suite 222, Irvine, CA 92697-5397
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Last updated on 2/17/2026.