Adrian Preda
•Professor of Clinical Psychiatry and Human Behavior, University of California Irvine
•Research Psychiatrist, UC Irvine Neuro-Psychiatric Center, UC Irvine Medical Center
Biography
Adrian Preda, M.D., DFAPA, is Professor of Clinical Psychiatry and Human Behavior at the University of California, Irvine (UCI) School of Medicine, where he has been a faculty member since 2006. A clinician-researcher and educator, Preda has built his career around the neuroscience of psychotic disorders and neuropsychiatric research, contributing to large-scale multisite imaging studies through consortia including the Function Biomedical Informatics Research Network (FBIRN) and the ENIGMA Schizophrenia Consortium. He has served as Principal Investigator on a range of federally and foundation-funded studies spanning schizophrenia neuroimaging, Alzheimer's disease clinical trials, and mood disorders. His scholarship, reflected in an h-index of 71 and more than 23,000 citations, spans peer-reviewed publications in journals including Science, Nature Communications, Biological Psychiatry, and the American Journal of Psychiatry.
At UCI, Preda has held numerous leadership roles, including Medical Director of the Neuropsychiatry Clinical Research Division, Executive Vice-Chair of the Department of Psychiatry and Human Behavior, Director of Residency Training in Psychiatry, and Director of the Esketamine Clinic. He is a Distinguished Fellow of the American Psychiatric Association and an elected member of both the American College of Psychiatry and the Group for the Advancement of Psychiatry. He is also a Fellow of the International College of Neuro-Psychopharmacology.
Preda has been broadly active in psychiatric education and publishing, serving as Editor-in-Chief of Psychiatric News, the flagship publication of the American Psychiatric Association, since 2024, as well as Editor-in-Chief for multiple StatPearls clinical titles and as an associate editor for several Frontiers journals. He received his M.D. from Carol Davila University of Medicine and Pharmacy in Bucharest, Romania, and completed his psychiatric residency at Yale University School of Medicine, where he also served as Chief Resident.
Return to topEducation
- B.S., Saint Sava National College, Bucharest, Romania, 1985
- M.D., Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 1992
Distinctions
- Distinguished Fellow, American Psychiatric Association, 2021-present
- Faculty Member (Full), Faculty of 1000 Medicine, 2019-present
- Elected Member, American College of Psychiatry, 2026-present
- Elected Member, Group for Advancement in Psychiatry, 2026-present
- Recognition of Promising New Thought Leaders, First Annual Psychiatry Chief Resident Program, 1999
- Fellow, International College of Neuro-Psychopharmacology, 2011-present
- Associate Faculty Member, Faculty of 1000 Medicine, 2008-2019
- NARSAD Young Investigator Award, 2001-2002
- NARSAD Elizabeth Elser Doolittle Investigator, 2002
- Profesor honoris causa in Artes Liberales, International Institute for Hermeneutics, 2021-present
Areas of Expertise
- Schizophrenia Spectrum Neuropsychiatry
- Diffusion Tensor Imaging Connectivity
- Antipsychotic Pharmacology Trials
- Functional Brain Network Dysconnectivity
- Alzheimer Neuroimaging Biomarkers
- AI-Induced Psychosis Phenomena
- Psychiatric Misinformation Public Scholarship
Recent Publications
- Lamsma J, Preda A, Nickl-Jockschat T, “Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium” (opens in new tab), Molecular Psychiatry, vol. 31, no. 4, pp. 2273-2282, 2026.
- Maksymchuk, Preda A, Calhoun VD, “Static and Dynamic Cross-Network Functional Connectivity Shows Elevated Entropy in Schizophrenia Patients” (opens in new tab), Human Brain Mapping, vol. 46, no. 2, pp. e70134, 2025.
- Behzadfar N, Preda A, Calhoun VD, “A multi-frequency ICA-based approach for estimating voxel wise frequency difference patterns in fMRI data” (opens in new tab), Aperture Neuro, vol. 5, 2025.
- Duda M, Preda A, Calhoun VD, “Alterations in Gray Matter Structure Linked to Frequency-Specific Cortico-Subcortical Connectivity in Schizophrenia via Multimodal Data Fusion” (opens in new tab), Neuroinformatics, vol. 23, no. 2, pp. 31, 2025.
- Soleimani N, Preda A, Calhoun VD, “Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs)” (opens in new tab), Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2025.
- Sendi MSE, Preda A, Calhoun VD, “Visualizing functional network connectivity differences using an explainable machine-learning method” (opens in new tab), Physiological Measurement, vol. 46, no. 4, 2025.
- Lella A, Preda A, Pergola G, “Thalamo-cortical structural co-variation networks are related to familial risk for schizophrenia in the context of lower nuclei volume estimates in patients: an ENIGMA study” (opens in new tab), Biological Psychiatry, vol. 98, pp. 698-711, 2025.
- Itkyal VS, Preda A, Calhoun VD, “Evidence for white matter intrinsic connectivity networks at rest and during a task: A large-scale study and templates” (opens in new tab), Network Neuroscience, vol. 9, no. 4, pp. 1221-1244, 2025.
- Iraji A, Preda A, Calhoun VD, “Spatial Dynamic Subspaces Encode Sex-Specific Schizophrenia Disruptions in Transient Network Overlap and Their Links to Genetic Risk” (opens in new tab), Biological Psychiatry, vol. 96, no. 3, pp. 188-197, 2024.
- Georgiadis F, Preda A, ENIGMA Schizophrenia Consortium, Bernhardt B, Kirschner M, “Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study” (opens in new tab), Molecular Psychiatry, vol. 29, pp. 1869-1881, 2024.
- Sharkey RJ, Preda A, Nickl-Jockschat T, “Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset” (opens in new tab), Molecular Psychiatry, vol. 29, pp. 3086-3096, 2024.
- Knol MJ, Preda A, Adams HHH, “Genetic variants for head size share genes and pathways with cancer” (opens in new tab), Cell Reports Medicine, vol. 5, no. 5, pp. 101529, 2024.
- Male AG, Preda A, van Erp TGM, “Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity” (opens in new tab), Psychiatry Research: Neuroimaging, vol. 342, pp. 111843, 2024.
- Kanyal A, Preda A, Ye DH, “Multi-modal deep learning from imaging genomic data for schizophrenia classification” (opens in new tab), Frontiers in Psychiatry, vol. 15, pp. 1384842, 2024.
- Jiang Y, Preda A, ENIGMA Schizophrenia Consortium, Feng J, “Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm” (opens in new tab), Nature Communications, vol. 15, no. 1, pp. 5996, 2024.
- Rahaman MA, Preda A, Calhoun V, “Imaging-genomic spatial-modality attentive fusion for studying neuropsychiatric disorders” (opens in new tab), Human Brain Mapping, vol. 45, no. 17, pp. e26799, 2024.
- Adrian Preda, Travis Smith, Rian Kabir, “Psychiatry Medical Student 2024 Edition: 610 Questions and Explanations” (opens in new tab), StatPearls Publishing LLC, 2024.
- Adrian Preda, Sasidhar Gunturu, “Consultation Liaison Psychiatry 2024 Edition: Board and Certification Review, 585 Questions and Explanations” (opens in new tab), StatPearls Publishing LLC, 2024.
- Constantinides C, Preda A, ENIGMA Schizophrenia Consortium, Walton E, “Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium” (opens in new tab), Molecular Psychiatry, vol. 28, no. 3, pp. 1201-1209, 2023.
Most Cited Publications
- Damaraju E, Preda A, Calhoun VD, “Dynamic functional connectivity analysis reveals transient states of dysconnectivity in schizophrenia” (opens in new tab), NeuroImage: Clinical, vol. 5, pp. 298-308, 2014.
- van Erp TG, Preda A, Turner JA, “Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium” (opens in new tab), Molecular Psychiatry, vol. 21, pp. 547-553, 2015.
- van Erp TGM, Preda A, Turner JA, “Cortical Brain Abnormalities in 4474 Individuals with Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta-Analysis (ENIGMA) Consortium” (opens in new tab), Biological Psychiatry, vol. 84, no. 9, pp. 644-654, 2018.
- Grasby KL, Preda A, Medland SE, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group, “The Genetic Architecture of the Human Cerebral Cortex” (opens in new tab), Science, vol. 367, no. 6484, 2020.
- Kelly S, Preda A, Donohoe G, “Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group” (opens in new tab), Molecular Psychiatry, vol. 23, no. 5, pp. 1261-1269, 2018.
- McGlashan TH, Zipursky RB, Perkins D, Addington J, Miller T, Woods SW, Hawkins KA, Hoffman RE, Preda A, Epstein I, Addington D, Lindborg S, Trzaskoma Q, Tohen M, Breier A, “Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis” (opens in new tab), American Journal of Psychiatry, vol. 163, no. 5, pp. 790-9, 2006.
- Potkin SG, Preda A, Lim KO, FBIRN, “Working memory and DLPFC inefficiency in schizophrenia: The FBIRN study” (opens in new tab), Schizophrenia Bulletin, vol. 35, no. 1, pp. 19-31, 2009.
- Radua J, Preda A, ENIGMA Consortium, van Erp TGM, “Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA” (opens in new tab), NeuroImage, vol. 218, pp. 116956, 2020.
- Glover GH, Preda A, Potkin SG, “Function biomedical informatics research network recommendations for prospective multicenter functional MRI studies” (opens in new tab), Journal of Magnetic Resonance Imaging, vol. 36, pp. 39-54, 2012.
- Writing Committee for the Attention-Deficit/Hyperactivity Disorder; Autism Spectrum Disorder; Bipolar Disorder; Major Depressive Disorder; Obsessive-Compulsive Disorder; and Schizophrenia ENIGMA Working Groups, Patel Y, Preda A, Paus T, “Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders” (opens in new tab), JAMA Psychiatry, vol. 78, pp. e202694, 2020.
- Miller RL, Yaesoubi M, Turner JA, Mathalon D, Preda A, Pearlson G, Adali T, Calhoun VD, “Higher Dimensional Meta-State Analysis Reveals Reduced Resting fMRI Connectivity Dynamism in Schizophrenia Patients” (opens in new tab), PLoS One, vol. 11, no. 3, pp. e0149849, 2016.
- Sui J, Preda A, Calhoun VD, “Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion” (opens in new tab), Nature Communications, vol. 9, no. 1, pp. 3028, 2018.
- Miller TJ, Preda A, McGlashan TH, “The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis. II. Baseline characteristics of the "prodromal" sample” (opens in new tab), Schizophrenia Research, vol. 61, no. 1, pp. 19-30, 2003.
- van Erp TG, Preda A, Potkin SG, FBIRN, “Converting positive and negative symptom scores between PANSS and SAPS/SANS” (opens in new tab), Schizophrenia Research, vol. 152, no. 1, pp. 289-94, 2014.
- McGlashan T, Preda A, Breier A, “Randomized, Double-Blind Trial of Olanzapine Versus Placebo in Patients Prodromally Symptomatic for Psychosis” (opens in new tab), Am J Psychiatry., vol. 163, no. 5, pp. 790-9, 2006 May.
Contact Information
Website: https://profiles.icts.uci.edu/adrian.preda
Email: adrian.preda@uci.edu
Phone: (714) 456-8688
Address: Orange, CA 92868, Rt. 88
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Last updated on 10/3/2026.