Andriy V. Yeromin
Biography
Dr. Andriy V. Yeromin is an Associate Project Scientist in the Department of Physiology and Biophysics and the Vaccine Research and Development Center at the University of California, Irvine. He received his Ph.D. in Biophysics from the Bogomoletz Institute of Physiology of the National Academy of Science of Ukraine in 2001. Yeromin co-discovered the molecular and biophysical mechanism of calcium release-activated channels (CRAC), a fundamental machinery for cellular signaling in mammals, contributing to multiple publications in Nature and PNAS that identified STIM1 and Orai1 as essential components of store-operated calcium channel function.
Yeromin has over 20 years of international experience in research on membrane protein physiology and pharmacology. His work has focused on understanding the structure and function of CRAC channels, including studies on Orai channel stoichiometry, nanoscale patterning during store-operated calcium entry, and functional heterogeneity in STIM1-Orai1 puncta. He has also contributed to research on calcium signaling in immune cells, particularly regulatory T cells, and on mitochondrial zinc accumulation in neuronal injury.
Yeromin has authored 19 peer-reviewed publications in journals including Nature, PNAS, and the Journal of General Physiology, as well as two book chapters. His technical expertise spans flow cytometry, patch-clamp electrophysiology, multi-photon imaging, molecular biology, and cell culture techniques. He has also served as a scientific consultant for Vivreon Biosciences and holds a patent related to CRAC channel modulator screening methods.
Return to topEducation
- Ph.D. in Biophysics, Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, 2001
- M.S. in Biophysics, Moscow Institute of Physics and Technology, 1996
Areas of Expertise
- Cellular Calcium Signaling
- CRAC Channel Biophysics
- Store-Operated Calcium Entry
- Orai1 Channel Structure
- Photoswitching Calcium Indicators
- Flow cytometry
- Electrophysiology
Recent Publications
- Hernandez-Davies J., Felgner J., Strahsburger E., Laster J., Jain A., Yates T., Silzel E., Assis R., Nakajima R., Jasinskas A., Yeromin A., Pone E.J., Jan S., de la Maza L.M., Liang L., Felgner P., Wagar L.E., Gregory A.E., Davies D.H., “Comparative evaluation of 5 combination adjuvants on immunogenicity and efficacy of approved seasonal influenza vaccines” (opens in new tab), Npj Vaccines, vol. 11, 2026.
- Manville RW, Yoshimura RF, Yeromin AV, Hogenkamp D, Van der Horst J, Zavala A, Chinedu S, Arena G, Lasky E, Fisher M, Tracy CR, Othy S, Jepps TA, Cahalan MD, Abbott GW, “Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines” (opens in new tab), Communications Biology, vol. 7, pp. 1059, 2024.
- Dynes JL, Yeromin AV, Cahalan MD, “Photoswitching alters fluorescence readout of jGCaMP8 Ca2+ indicators tethered to Orai1 channels” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 39, pp. e2309328120, 2023.
- Medvedeva YV, Yin HZ, Bazrafkan A, Yeromin A, Ji SG, Weiss-Hung EJ, Sharman E, Avilez AP, Maki N, Rafi MA, Tian G, Akbari Y, Weiss JH, “Blocking mitochondrial Zn²⁺ accumulation after ischemia reduces mitochondrial dysfunction and neuronal injury” (opens in new tab), Journal of Neuroscience, vol. 42, no. 26, pp. 5281-5292, 2022.
- Jairaman A, Othy S, Dynes JL, Yeromin AV, Zavala A, Greenberg ML, Nourse JL, Holt JR, Cahalan SM, Marangoni F, Parker I, Pathak MM, Cahalan MD, “Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses” (opens in new tab), Science Advances, vol. 7, no. 28, pp. eabg5859, 2021.
- Othy S, Jairaman A, Dynes JL, Dong TX, Tune C, Yeromin AV, Zavala A, Akunwafo C, Chen F, Parker I, Cahalan MD, “Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 33, pp. 20088-20099, 2020.
- Dynes JL, Yeromin AV, Cahalan MD, “Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta” (opens in new tab), Journal of General Physiology, vol. 152, no. 9, pp. e201812239, 2020.
- Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, et al., “iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases” (opens in new tab), Neuron, vol. 94, pp. 278-293, 2017.
- Perni S, Dynes JL, Yeromin AV, Cahalan MD, Franzini-Armstrong C, “Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry”, PNAS, vol. 112, pp. E5533-E5542, 2015.
- Amcheslavsky A, Wood ML, Yeromin AV, Parker I, Freites JA, Tobias DJ, Cahalan MD, “Molecular biophysics of Orai store-operated Ca2+ channels” (opens in new tab), Biophysical Journal, vol. 108, pp. 237-246, 2015.
- Amcheslavsky A, Yeromin AV, Penna A, Cahalan MD, “Store-Operated Calcium Channels” (opens in new tab), Encyclopedia of Biological Chemistry Second Edition, Elsevier, pp. 314-320, 2013.
- Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, Parker I, “Subunit stoichiometry of human Orai1 and Orai3 in closed and open states” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 108, pp. 17832-17837, 2011.
- Zhang SL, Yeromin AV, Hu J, Amcheslavsky A, Zheng H, Cahalan MD, “Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 108, pp. 17838-17843, 2011.
- Penna A, Zhang SL, Yeromin AV, Cahalan MD, “Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by Stim & Orai” (opens in new tab), Handbook of Cell Signaling Second Edition, Elsevier, vol. 1, pp. 209-216, 2009.
- Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD, “The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers” (opens in new tab), Nature, vol. 456, pp. 116-120, 2008.
- Zhang SL, Kozak JA, Jiang W, Yeromin AV, Chen J, Yu Y, Penna A, Shen W, Chi V, Cahalan MD, “Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3” (opens in new tab), Journal of Biological Chemistry, vol. 283, pp. 17662-71, 2008.
- Cahalan M, Zhang S, Yeromin A, “CRAC channel and modulator screening methods”, 2008. Patent No. US 20080039392 A1.
- Cahalan MD, Zhang SL, Yeromin AV, Ohlsen K, Roos J, Stauderman KA, “Molecular basis of the CRAC channel” (opens in new tab), Cell Calcium, vol. 42, pp. 133-44, 2007.
- Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD, “Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai” (opens in new tab), Nature, vol. 443, pp. 226-229, 2006.
- Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD, “Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 9357-9362, 2006.
Most Cited Publications
- Roos J, Digregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Velicelebi G, Stauderman KA, “STIM1, an essential and conserved component of store-operated Ca2+ channel function” (opens in new tab), Journal of Cell Biology, vol. 169, pp. 435-445, 2005.
- Yeromin A, Roos J, Stauderman KA, Cahalan M, “A store-operated calcium channel in Drosophila S2 cells” (opens in new tab), Journal of General Physiology, vol. 123, pp. 167-182, 2004.
Contact Information
Email: ayeromin@uci.edu
Phone: (949) 824-0460
Address: FLFMIB, 847 Health Sciences Road, Irvine, CA 92697
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Last updated on 5/22/2026.