Craig E. L. Stark
Biography
Craig E. L. Stark, Ph.D., is Professor in the Departments of Neurobiology and Behavior and Cognitive Sciences at the University of California, Irvine, where he also serves as Director of the Campus Center for Neuro-Imaging (CCNI) and Director of the Facility for Imaging and Brain Research (FIBRE). He additionally serves as Biomarker Core Leader for the UCI Alzheimer's Disease Research Center (ADRC). From 2016 to 2022, he held the James L. McGaugh Chair in Neurobiology of Learning and Memory. His research focuses on the structure and function of the medial temporal lobe memory system, with particular emphasis on hippocampal pattern separation and its decline in aging and Alzheimer's disease.
Stark is known for developing the Mnemonic Similarity Task (MST), a behavioral and neuroimaging tool for assessing hippocampal integrity that has been widely adopted in studies of aging, mild cognitive impairment, and Alzheimer's disease. His lab applies high-resolution structural and functional MRI, diffusion tensor imaging, and MR spectroscopy to examine hippocampal subfield function across the human lifespan. He has maintained continuous NIH funding across his career, supporting work that spans translational animal models, human neuroimaging, and the development of digital biomarkers for Alzheimer's disease. He is a Fellow of the American Association for the Advancement of Science and a Fellow of the Association for Psychological Science.
Stark has contributed extensively to public education on the neuroscience of memory, including recurring participation in judicial education programs organized by the AAAS, the Federal Judicial Center, and the Dana Foundation. He received his Ph.D. in Cognitive Psychology from Carnegie Mellon University, where he trained under James McClelland, and completed postdoctoral training at the University of California, San Diego under Larry Squire.
Return to topEducation
- A.B., Harvard University, 1992
- Ph.D. in Cognitive Psychology, Carnegie Mellon University, 1997
- Postdoctoral Fellow, University of California, San Diego, 2001
Distinctions
- Fellow of the American Association for the Advancement of Science (AAAS), 2018-present
- Fellow for the Association for Psychological Science (APS), 2018-present
- Top-cited article 2021-2022, Hippocampus journal, 2021-2022
- James L. McGaugh Chair in Neurobiology of Learning and Memory, 2016-2022
- Faculty Member, Faculty of 1000 Cognitive Neuroscience division, 2010-present
- Member of the Dana Alliance for Brain Initiatives, 2011-present
- Department of Psychology Faculty Prize, Harvard University, 1992
- UCI Innovator of the Year Finalist, UC Irvine, 2020
- McDonnell-Pew Center for Cognitive Neuroscience Postdoctoral Fellow, UCSD, 1997
- Magna Cum Laude with Highest Honors, Harvard University, 1992
Areas of Expertise
- Cognitive Neuroscience of Human Memory
- Hippocampal Pattern Separation
- Medial Temporal Lobe fMRI
- Age-Related Mnemonic Decline
- Mnemonic Similarity Task Development
- Alzheimer's Disease Biomarkers
- Environmental Enrichment Cognitive Enhancement
Recent Publications
- Vanderlip C.R., Lingad J.N., Treadwell Z., Loritsch J.M., Illeck C.L., Ubele M.F., Boaz K., Mefford J.L., Jones E.D., Perpich J.A., McCarty K., Meacham B., Bembenek Bailey S.A., Puskas L.G., Bresch F., Powell D.K., Norris C.M., Head E., Stark C.E.L., “Amyloid-associated cognitive trajectories in aging dogs mirror early changes in humans” (opens in new tab), Neurobiology of Aging, vol. 168, pp. 99-108, 2026.
- Azer L., Vanderlip C.R., Ehlert L., Stark C.E.L., “A systematic evaluation of the oMST's alternate stimulus sets, languages, and contaminant detection methods” (opens in new tab), Neuropsychologia, vol. 232, 2026.
- Vanderlip C.R., Dunn S.R., Asch P.A., Stark C.E.L., Glavis-Bloom C., “A scalable touchscreen-based spatial working memory task for cross-species research” (opens in new tab), Neurobiology of Learning and Memory, vol. 227, 2026.
- Vanderlip C.R., Salim H., Houle A., Cortes A., Virovka A., Liang Y., Luc K., Kellogg A., Stark C.E.L., “Attentional Deficits Do Not Explain Age-Related Impairments on the Mnemonic Similarity Task” (opens in new tab), Hippocampus, vol. 36, 2026.
- Vanderlip C.R., Gillen D.L., Grill J.D., Stark C.E.L., “Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer’s trials” (opens in new tab), Journal of Prevention of Alzheimer S Disease, vol. 13, 2026.
- Azer L., Vanderlip C.R., Mayer L.L., Ehlert L., Sultzer D., Shin H.-W., Stark C.E.L., “MST in the wild: Optimizing the mnemonic similarity task for use in diverse environments” (opens in new tab), Neuropsychologia, vol. 221, 2026.
- Lingad J.N., Vanderlip C.R., Wright S., Sordo L., Head E., Stark C.E.L., “Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer’s continuum” (opens in new tab), Neurobiology of Aging, vol. 157, pp. 89-97, 2026.
- Vanderlip CR, Stark CEL, “Time course and severity of cognitive changes as a function of Aβ positivity and APOE genotype in Alzheimer's Disease” (opens in new tab), Neurology, vol. 105, 2025.
- Vanderlip CR, Stark CEL, “Integrating Plasma pTau-217 and Digital Cognitive Assessments for Early Detection in Alzheimer's Disease” (opens in new tab), Alzheimer's and Dementia, vol. 21, 2025.
- Ren Y, Shahbaba B, Stark CEL, “Identifying dementia neuropathology using low-burden clinical data” (opens in new tab), Alzheimer S and Dementia, vol. 21, 2025.
- Kimbler A., Stark C.E.L., “Advanced diffusion imaging in grey matter reflects individual differences in cognitive ability in older adults” (opens in new tab), Imaging Neuroscience, vol. 3, 2025.
- Trinh M, Shahbaba R, Stark C, Ren Y, “Alzheimer's Disease detection using data fusion with deep supervised encoder” (opens in new tab), Frontiers in Dementia, vol. 3, 2024.
- Tao Y, Schubert T, Wiley R, Stark C, Rapp B, “Cortical and subcortical mechanisms of orthographic word-form learning” (opens in new tab), Journal of Cognitive Neuroscience, vol. 36, no. 6, pp. 1071-1098, 2024.
- Noche J, Radhakrishnan H, Ubele M, Boaz K, Mefford J, Jones E, Perpich J, McCarty K, Meacham B, Smiley J, Baily SB, Puskás L, Powell D, Sordo L, Phelan M, Norris C, Head E, Stark C, “Age-related brain atrophy and the positive effects of behavioral enrichment in middle-aged beagles” (opens in new tab), The Journal of Neuroscience, vol. 44, 2024.
- Dominguez EN, Corrada MM, Kawas CH, Stark CEL, “Resilience to AD pathology in top cognitive performers” (opens in new tab), Frontiers in Aging Neuroscience, vol. 16, 2024.
- Vanderlip CR, Stark CEL, “Digital cognitive assessments as low-burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum” (opens in new tab), Alzheimer's and Dementia, vol. 20, pp. 6881-6895, 2024.
- Vanderlip CR, Lee MD, Stark CEL, “Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's Disease” (opens in new tab), Alzheimer's and Dementia, vol. 20, pp. 6935-6947, 2024.
- Mazloum-Farzaghi N, Barense MD, Ryan JD, Stark CEL, Olsen RK, “The effect of segmentation method on medial temporal lobe subregion volumes in aging” (opens in new tab), Human Brain Mapping, vol. 45, 2024.
- Lee MD, Stark CEL, “Bayesian Modeling of the Mnemonic Similarity Task Using Multinomial Processing Trees” (opens in new tab), Behaviormetrika, vol. 50, pp. 517-539, 2023.
- Stark CEL, Noche J, Ebersberger J, Mayer L, Stark SM, “Optimizing the Mnemonic Similarity Task for Efficient, Widespread Use” (opens in new tab), Frontiers in Behavioral Neuroscience, vol. 17, 2023.
Most Cited Publications
- Squire LR, Stark CEL, Clark RE, “The medial temporal lobe” (opens in new tab), Annual Review of Neuroscience, vol. 27, pp. 279-306, 2004.
- Yassa MA, Stark CEL, “Pattern separation in the hippocampus” (opens in new tab), Trends in Neurosciences, vol. 34, no. 10, pp. 515-525, 2011.
- Bakker A, Kirwan CB, Miller MI, Stark CEL, “Pattern separation in the human hippocampal CA3 and dentate gyrus” (opens in new tab), Science, vol. 319, no. 5870, pp. 1640-1642, 2008.
- Stark CEL, Squire LR, “When zero is not zero: The problem of ambiguous baseline conditions in fMRI” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 22, pp. 12760-12766, 2001.
- Yassa MA, Lacy JW, Stark SM, Albert MS, Gallagher M, Stark CEL, “Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults” (opens in new tab), Hippocampus, vol. 21, pp. 968-979, 2011.
- Stark SM, Yassa MA, Lacy JW, Stark CEL, “A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment” (opens in new tab), Neuropsychologia, vol. 51, no. 12, pp. 2442-2449, 2013.
- Yassa MA, Stark SM, Bakker A, Albert MS, Gallagher M, Stark CEL, “High-resolution functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment” (opens in new tab), Neuroimage, vol. 51, pp. 1242-1252, 2010.
- Yassa MA, Mattfeld AM, Stark SM, Stark CEL, “Age-related memory deficits linked to circuit-specific disruptions in the hippocampus” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 21, pp. 8873-8878, 2011.
- Lacy JW, Yassa MA, Stark SM, Stark CEL, “Distinct pattern separation related transfer functions in human CA1 and CA3/DG revealed using high-resolution fMRI and mnemonic similarity” (opens in new tab), Learning and Memory, vol. 18, pp. 15-18, 2011.
- Kirwan CB, Stark CEL, “Overcoming interference: An fMRI investigation of pattern separation in the medial temporal lobe” (opens in new tab), Learning and Memory, vol. 14, pp. 625-633, 2007.
Contact Information
Website: https://faculty.sites.uci.edu/starklab
Email: cestark@uci.edu
Phone: (949) 824-4201
Address: 1424 Biological Sciences III
Return to topThis profile was created with the help of AI.
Last updated on 9/15/2026.