Skip to main content
Anastasia Chumakova

Anastasia Chumakova

Assistant HS Professor, Department of Neurology

Biography

Anastasia Chumakova, M.D., is Assistant HS Professor in the Department of Neurology at the University of California, Irvine. She received her M.D. magna cum laude from Lomonosov Moscow State University Faculty of Medicine in 2014, followed by a neurosurgery internship at Burdenko Neurosurgery Institute in Moscow. After completing a postdoctoral fellowship in cell biology at Cleveland Clinic Lerner Research Institute, she transitioned to clinical training at UC Irvine, where she completed her internal medicine internship, neurology residency, and fellowship in multiple sclerosis and neuroimmunology. She served as chief resident during her neurology training and became board certified in neurology in 2023.

Chumakova's research focuses on serum biomarkers of neuronal damage and neuroinflammation in multiple sclerosis patients, particularly those receiving B-cell depleting therapies. Her work examines the relationship between BAFF levels, hypogammaglobulinemia, and markers of neuroaxonal damage in patients on ocrelizumab. She has published in journals including Journal of Neuroinflammation, JCI Insight, Cytometry Part A, and Journal of Experimental Medicine, with research spanning from glioblastoma stem cell biology during her postdoctoral work to current investigations in neuroimmunology.

Chumakova maintains an active clinical practice in neuroimmunology, seeing patients with multiple sclerosis, neuromyelitis optica, MOG-associated disease, autoimmune encephalitis, and other autoimmune neurological conditions. She has established a dedicated inpatient neuroimmunology consultation service at UC Irvine Medical Center and mentors multiple neurology residents and medical students on research projects involving serum biomarkers and clinical outcomes in neuroimmunological diseases.

Return to top

Education

  • M.D., Lomonosov Moscow State University, 2014
Return to top

Distinctions

  • Outstanding Research Presentation by Resident, 22nd Annual Research Day, 2021
  • ED Consultant of the month, 2020
  • Young Scientist Award, Russian Academy of Sciences, 2012
Return to top

Areas of Expertise

  • Neuroimmunology
  • Multiple Sclerosis Biomarkers
  • Autoimmune Encephalitis
  • B-Cell Depleting Therapies
  • Hypogammaglobulinemia Mechanisms
  • Acute treatments in neuroimmunology

Recent Publications

  • Chumakova A., McKay L., Fleming V., Demetriou M., Sy M., “BAFF is a marker of hypogammaglobulinemia, neuroaxonal damage and inflammation in multiple sclerosis patients on ocrelizumab” (opens in new tab), Journal of Neuroinflammation, vol. 23, 2026.
  • Avelar J, Wencel M, Chumakova A, Mozaffar T, “COVID-19 infection in patients with late-onset Pompe disease” (opens in new tab), Muscle and Nerve, vol. 65, no. 3, pp. 334-336, 2022.
  • Hitomi M, Chumakova AP, Silver DJ, Knudsen AM, Pontius WD, Murphy S, Anand N, Kristensen BW, Lathia JD, “Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells”, JCI Insight, vol. 6, no. 3, pp. e130510, 2021.
  • Chumakova A, Hitomi M, Sulman E, Lathia JD, “High-throughput Automated Single Cell Imaging Analysis (HASCIA) Reveals Dynamics Of Glioblastoma Stem Cell Population During State Transition”, Cytometry Part A, vol. 95, no. 3, pp. 290-301, 2019.
  • Esakov EL, Hale J, Richards EG, Torre-Healy L, Gullapalli K, Trivedi D, Chumakova A, Wessely O, Jensen J, Lathia J, Reizes O, “Therapeutic strategies to induce ERα in luminal breast cancer to enhance tamoxifen efficacy”, Endocr Relat Cancer, vol. 26, no. 8, pp. 689-698, 2019.
  • Chumakova A., Lathia J.D., “Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight”, Journal of Neurochemistry, 2018.
  • Saygin C, Wiechert A, Rao V, Alluri R, Connor E, Thiagarajan P, Hale J, Li Y, Chumakova A, Jarrar A, Parker Y, Lindner D, Nagaraj A, Kim J, DiFeo A, Abdul-Karim F, Michener C, Rose P, DeBernardo R, Mahdi H, et al., “CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors”, Journal of Experimental Medicine, vol. 214, no. 9, pp. 2715-2732, 2017.
  • Dashzeveg N.K., Taftaf R., Ramos E.K., Torre-Healy L., Chumakova A., Silver D.J., Alban T.J., Sinyuk M., Thiagarajan P.S., Jarrar A.M., Turaga S.M., Saygin C., Mulkearns-Hubert E., Hitomi M., Rich J.N., Gerson S.L., Lathia J.D., Liu H., “New Advances and Challenges of Targeting Cancer Stem Cells”, Cancer Research, vol. 77, no. 19, pp. 5222-5227, 2017.
  • Potapov A.A., Goryaynov S.A., Okhlopkov V.A., Shishkina L.V., Loschenov V.B., Savelieva T.A., Golbin D.A., Chumakova A.P., Goldberg M.F., Varyukhina M.D., Spallone A., “Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection”, Neurosurgical Review, vol. 39, no. 3, pp. 437-47, 2016.
  • Saygin C., Samour M., Chumakova A., Jarrar A., Lathia J.D., Reizes O., “Reporter Systems to Study Cancer Stem Cells”, Stem Cell Heterogeneity. Methods in Molecular Biology, vol. 1516, pp. 319-333, 2016.
  • Potapov A.A., Goryaynov S.A., Okhlopkov V.A., Pitskhelauri D.I., Kobyakov G.L., Zhukov V.Y., Gol'bin D.A., Svistov D.V., Martynov B.V., Krivoshapkin A.L., Gaytan A.S., Anokhina Y.E., Varyukhina M.D., Gol'dberg M.F., Kondrashov A.V., Chumakova A.P., “Clinical guidelines for the use of intraoperative fluorescence diagnosis in brain tumor surgery”, Zhurnal voprosy neiyrokhirurgii imeni N. N. Burdenko, vol. 79, no. 5, pp. 91-101, 2015.
  • Buklina S.B., Batalov A.I., Fadeeva L.M., Smirnov A.S., Goryaynov S.A., Zhukov V.Y., Poddubskaya A.A., Ogurtsova A.A., Kulikov A.S., Chumakova A.P., Pronin I.N., Kornienko V.N., Potapov A.A., “The structure of activation of the language zone in patients with intracerebral tumors according to fMRI with respect to tumor location and the functional asymmetry profile”, Zhurnal voprosy neiyrokhirurgii imeni N. N. Burdenko, vol. 79, no. 3, pp. 60-68, 2015.
  • Goriaynov S.A., Potapov A.A., Pitskhelauri D.I., Kobiakov G.L., Okhlopkov V.A., Gavrilov A.G., Shurkhay V.A., Zhukov V.Iu., Shishkina L.V., Loshchenov V.B., Savel'eva T.A., Kuz'min S.G., Chumakova A.P., Spallone A., “Intraoperative fluorescence diagnostics upon recurrent operations for brain gliomas”, Zhurnal voprosy neiyrokhirurgii imeni N. N. Burdenko, vol. 78, no. 2, pp. 22-31, 2014.
  • Potapov A.A., Goriaynov S.A., Loshchenov V.B., Savel'eva T.A., Gavrilov A.G., Okhlopkov V.A., Zhukov V.Iu., Zelenkov P.V., Gol'bin D.A., Shurkhay V.A., Shishkina L.V., Grachev P.V., Kholodtsova M.N., Kuz'min S.G., Vorozhtsov G.N., Chumakova A.P., “Intraoperative combined spectroscopy (optical biopsy) of cerebral gliomas”, Zhurnal voprosy neiyrokhirurgii imeni N. N. Burdenko, vol. 77, no. 2, pp. 3-10, 2013.
Return to top

Contact Information

Email: chumakoa@uci.edu

Phone: (714) 456-3420

Address: 200 S. Manchester Ave. Ste 206, Irvine, CA 92697-4280

Return to top

This profile was created with the help of AI.

Last updated on 8/15/2026.