Diane J. Nugent
Biography
Diane J. Nugent, M.D., is Clinical Professor and Chief of Hematology in the Department of Pediatrics at the University of California Irvine School of Medicine and Director and Chief of Hematology at Children's Hospital of Orange County. She received her medical degree from the University of California, Los Angeles, and completed a Pediatric Hematology-Oncology Research Fellowship at the Fred Hutchinson Cancer Research Center and Children's Hospital and Medical Center in Seattle. Nugent founded and serves as Medical Director of the Center for Comprehensive Care and Diagnosis of Inherited Blood Disorders, a federally funded community-based clinic for adults and children. Her research focuses on immune thrombocytopenic purpura, rare bleeding disorders including factor XIII deficiency, and platelet function disorders.
Nugent has held numerous leadership positions in national and international organizations. She served on the National Heart, Lung and Blood Advisory Council at the National Institutes of Health from 2016 to 2020 and co-chaired the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee Platelet Physiology from 2005 to 2023. She served as President of the Hemostasis Thrombosis Research Society from 2014 to 2016 and has been a member of the American Society of Hematology Government Affairs Committee since 2006. Nugent has directed multiple federally funded programs, including the Region IX Hemophilia Treatment Center and served as Principal Investigator for the Maternal and Child Health Bureau Hemophilia Program and CDC Community Counts surveillance initiatives.
Nugent has authored over 190 peer-reviewed publications and has been Principal Investigator on multiple NIH grants studying the pathogenesis of autoimmune thrombocytopenia and molecular diagnosis of bleeding disorders. She has served on numerous NIH study sections, including as Chairman of the NHLBI Transfusion Medicine/Hemostasis Study Review Committee from 2005 to 2010. She received the National Hemophilia Foundation Physician of the Year Award in 2006 and the Physician of the Year Award from the Orange County Medical Association in 2005. Nugent has been instrumental in healthcare policy initiatives, including co-leading the California State Action Planning Initiative for Sickle Cell Disease and contributing to the passage of AB 1105, California's Sickle Cell State Planning Initiative.
Return to topEducation
- M.D., University of California, Los Angeles, 1977
- B.A. in Fine Arts, University of California, Irvine, 1971
Distinctions
- Coopersmith Visiting Professorship, Department of Pediatrics, Johns Hopkins Medical School, 2010
- Women Leaders in Hematology: Inspirations & Insights, American Journal of Hematology, 2016
- National Hemophilia Foundation Physician of the Year Award, 2006
- American Cancer Society Junior Faculty Clinical Fellowship, 1984-1986
- CAL-Optima Circle of Care Award, 2011
- Best Doctors in America, Woodward/White, 1998
- Best Doctors in America, 2007-2010
- Reader's Choice Top Women in Healthcare, Orange Coast Magazine, 2019
- Academic Faculty Research Award, Bascom Hill Society of University of Wisconsin Madison, 1992
- Bruce Graber Memorial Award for Outstanding Resident in Pediatrics, University of Colorado, 1980
Areas of Expertise
- Pediatric Hematology
- Immune Thrombocytopenic Purpura
- Platelet Glycoprotein Polymorphisms
- Hemophilia Treatment Centers
- Factor XIII Deficiency
- Sickle Cell Disease Management
- COVID-19 Associated Coagulopathy
Recent Publications
- Antonio Arrieta, Alvaro E. Galvis, Stephanie Osborne, Tricia Morphew, Karen Imfeld, Claudia Enriquez, Janet Hoang, Marcia Swearingen, Delma J. Nieves, Negar Ashouri, Jasjit Singh, Diane Nugent, “Use of COVID-19 Convalescent Plasma for Treatment of Symptomatic SARS-CoV-2 Infection at a Children's Hospital: A Contribution to a Still Inadequate Body of Evidence” (opens in new tab), Children, vol. 10, no. 2, pp. 350, 2023.
- D Nugent, SS Acharya, KJ Baumann, C Bedrosian, R Bialas, K Brown, D Corzo, A Haidar, C Hayward, P Marks, M Menegatti, ME Miller, K Nammacher, AS Wolberg, A Shapiro, “Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: research priorities for ultra-rare inherited bleeding” (opens in new tab), Expert Review of Hematology, vol. 16, pp. 55-70, 2023.
- Mammen EF, Comp PC, Gosselin R, Greenberg C, Hoots WK, Kessler CM, Larkin EC, Liles D, Nugent DJ, “PFA-100 System: A New Method for Assessment of Platelet Dysfunction” (opens in new tab), Seminars in Thrombosis and Hemostasis, vol. 50, pp. 664-671, 2023.
- Kyung Moon, James Morrissey, Edward Conway, Nigel Mackman, Ronald Warren, Laurent Mosnier, Karin Hoffmeister, Robert Campbell, Matthew Rondina, Frank van de Veerdonk, Lisa Gralinski, John Griffin, Alisa Wolberg, Diane Nugent, “Understanding COVID-19-associated coagulopathy” (opens in new tab), Nature Reviews Immunology, vol. 22, pp. 639-649, 2022.
- Marsha J. Treadwell, Lisa Du, Neha Bhasin, Anne M. Marsh, Theodore Wun, MA Bender, Trisha E. Wong, Nicole Crook, Jong H. Chung, Shannon Norman, Nicolas Camilo, Judith Cavazos, Diane Nugent, “Barriers to hydroxyurea use from the perspectives of providers, individuals with sickle cell disease, and families: Report from a U.S. regional collaborative” (opens in new tab), Frontiers in Genetics, vol. 13, pp. 921432, 2022.
- JS Buzby, SA Williams, DJ Nugent, “Unaffected Li-Fraumeni Syndrome Carrier Parent Demonstrates Allele-Specific mRNA Stabilization of Wild-Type TP53 Compared to Affected Offspring” (opens in new tab), Genes, vol. 13, no. 12, pp. 2302, 2022.
- Arrieta A, Galvis A, Morphew T, Ehwerhemuepha L, Osborne S, Enriquez C, Imfeld K, Hoang J, Nieves D, Ashouri N, Singh J, Nugent D, “Safety and Antibody Kinetics of COVID-19 Convalescent Plasma for the Treatment of Moderate to Severe Cases of SARS-CoV-2 Infection in Pediatric Patients” (opens in new tab), Pediatric Infectious Disease Journal, vol. 40, no. 7, pp. 606-611, 2021.
- Theodore W. Heyming, Diane Nugent, Aprille Tongol, Chloe Knudsen-Robbins, Janet Hoang, John Schomberg, Kellie Bacon, Bryan Lara, Terence Sanger, “Rapid antibody testing for SARS-CoV-2 vaccine response in pediatric healthcare workers” (opens in new tab), International Journal of Infectious Diseases, vol. 113, pp. 1-6, 2021.
- HeymingT, Nugent D, tongol A, Kundsen-Robbins C, Bacon K, Hoang J, Sanget T, “Rapid Antibody Testing for SARS-CoV-2 Vaccine Response Amont Pediatric Health Care Workers” (opens in new tab), Ann Emerg Med, vol. 78, no. 2, pp. S27, 2021.
Most Cited Publications
- Mammen EF, Comp PC, Gosselin R, Greenberg C, Hoots W, Kessler CM, Larkin EC, Liles D, Nugent DJ, “PFA-100TM system: a new method for assessment of platelet dysfunction” (opens in new tab), Seminars in Thrombosis and Hemostasis, vol. 24, no. 2, pp. 195-202, 1998.
- Chang M, Nakagawa PA, Williams SA, Schwartz MR, Imfeld KL, Buzby JS, Nugent DJ, “Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro” (opens in new tab), Blood, vol. 102, no. 3, pp. 887-895, 2003.
- Kunicki TJ, Kritzik M, Annis DS, Nugent DJ, “Hereditary variation in platelet integrin α₂β₁ density is associated with two silent polymorphisms in the α2 gene coding sequence” (opens in new tab), Blood, vol. 89, no. 6, pp. 1939-1943, 1997.
- P Gresele, Subcommittee on Platelet Physiology of the international Society on Thrombosis and Hemostasis, “Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH” (opens in new tab), Journal of Thrombosis and Haemostasis, vol. 13, no. 2, pp. 314-22, 2015.
- Nugent D, McMillan R, Nichol JL, Slichter SJ, “Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and/or decreased platelet production” (opens in new tab), British Journal of Haematology, vol. 146, no. 6, pp. 585-96, 2009.
- Kunicki TJ, Nugent DJ, Staats SJ, Orchekowski RP, Wayner EA, Carter WG, “The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex”, Journal of Biological Chemistry, vol. 263, no. 10, pp. 4516-4519, 1988.
- Shulman H, Gown AM, Nugent DJ, “Hepatic veno-occlusive disease after bone marrow transplantation: Immunohistochemical identification of the material within occluded central venules”, American Journal of Pathology, vol. 127, no. 3, pp. 549-558, 1987.
- Hsieh L, Nugent DJ, “Factor XIII Deficiency” (opens in new tab), Haemophilia, vol. 14, no. 6, pp. 1190-2000, 2008.
- DiPaola J, Federici AB, Mannucci PM, Canciani MT, Kritzik M, Kunicki TJ, Nugent DJ, “Low Platelet α₂β₁ Levels in type I von Willebrand disease correlate with impaired platelet function in a high shear stress system” (opens in new tab), Blood, vol. 93, no. 11, pp. 3578-3582, 1999.
- Piotrowicz RS, Orchekowski RP, Nugent DJ, Yamada KM, Kunicki TJ, “Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets” (opens in new tab), Journal of Cell Biology, vol. 106, no. 4, pp. 1359-1364, 1988.
Contact Information
Email: dnugent@uci.edu
Phone: (714) 509-8459
Address: 1201 W. LaVeta Ave., Irvine, CA 92868
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Last updated on 2/19/2026.