Biography
Vy Maria Dong, Ph.D., is Chancellor's Professor in the Department of Chemistry at the University of California, Irvine. She received her Ph.D. in organic chemistry from the California Institute of Technology, where she worked on Claisen rearrangements and the total synthesis of erythronolide B with Professor David MacMillan. Dong completed postdoctoral training at the University of California, Berkeley, studying organometallic chemistry, physical organic chemistry, and supramolecular chemistry with Professors Robert Bergman and Kenneth Raymond. She joined the faculty at the University of Toronto in 2006 as an Assistant Professor, was promoted to Associate Professor in 2010, and moved to the University of California, Irvine, as Full Professor in 2012.
Dong's research focuses on transition-metal catalysis, particularly rhodium- and cobalt-catalyzed hydroacylation, hydroamination, and hydrofunctionalization reactions. Her group has developed enantioselective methods for forming carbon-carbon and carbon-heteroatom bonds, including approaches to lactones, heterocycles, and complex natural products. Notable contributions include the development of dynamic kinetic resolution strategies, transfer hydroformylation for carbon-carbon bond cleavage, and catalytic methods for alkyne and diene functionalization. Her work has expanded the scope of hydroacylation to include non-chelating aldehydes and has established new paradigms for enantioselective catalysis using sulfoxide ligands and tandem catalytic systems.
Dong is an Arthur C. Cope Scholar and has received the ACS Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis by a Young Investigator. She serves as Editor for Organic Syntheses and for the Royal Society of Chemistry's Chemical Society Reviews, and is an External Consultant with Merck & Co. Dong has mentored over 20 doctoral students and numerous postdoctoral fellows who have gone on to positions in academia and industry. She is the author of "Office Hours: Unlocking Your Potential in Organic Chemistry and Beyond," published in 2025.
Return to topEducation
- B.S. in Chemistry, University of California, Irvine, 1998
- M.S. in Organic Chemistry, University of California, Berkeley, 2000
- Ph.D. in Organic Chemistry, California Institute of Technology, 2003
Distinctions
- Royal Society of Chemistry (RSC), Merck, Sharp & Dohme Award, 2020
- ACS Elias J. Corey Award, Outstanding Original Contribution in Organic Synthesis by a Young Investigator, 2019
- ACS Arthur C. Cope Scholar Award, 2010
- American Chemical Society Poster Award Winner, Pacifichem ACS Conference, 2000
- National Science Foundation Graduate Research Fellowship, 1999-2003
- Newkirk Fellow, University of California, Irvine, 2025
- The Society of Synthetic Organic Chemistry, Japan, Lectureship, 2013
- Alfred P. Sloan Research Fellowship, 2009-2011
- Division of Teaching Excellence and Innovation (DTEI) UC Online Award, 2025
- Japan Society for the Promotion of Science Fellowship, 2013
Areas of Expertise
- Organometallic Catalysis
- Enantioselective Hydroacylation
- Rhodium-Catalyzed Transformations
- Palladium-Catalyzed Functionalization
- Copper-Hydride Catalysis
- Cyclopropene Desymmetrization
- Yttrium-Catalyzed Phosphoramidate Synthesis
Recent Publications
- Daniels, B. S., Blackburn, B. G., Scribner, S. J., Dong, V. M., “Pathway to P(V)-Stereogenic Phosphoramidates by Enantioselective Yttrium Catalysis” (opens in new tab), Journal of the American Chemical Society, vol. 147, no. 25, pp. 21339-21346, 2025.
- Xu, M., Corio, S. A., Warnica, J. M., Kuker, E. L., Lu, A., Hirschi, J. S., Dong, V. M., “Dynamic Kinetic Asymmetric Hydroacylation: Racemization by Soft Enolization” (opens in new tab), Journal of the American Chemical Society, vol. 147, no. 19, pp. 16270-16281, 2025.
- Senzer, B. D., Varongchayakul, C., Danheiser, R. L., Daniels, B., Dong, V. M., “Purification of Organic Compounds by Flash Column Chromatography” (opens in new tab), Org. Synth., vol. 102, pp. 276–302, 2025.
- Dong, V., “Office Hours: Unlocking Your Potential in Organic Chemistry and Beyond”, Macmillan, 2025.
- Phun, G. S., Slocumb, H. S., Ruud, K. J., Nie, S., Antonio, C., Furche, F., Dong, V. M., “Hydroselenation of Olefins: Elucidating the β-Selenium Effect” (opens in new tab), Chemical Science, vol. 15, no. 48, pp. 20523-20533, 2024.
- Li, Q., Wang, Z., Yang, X., Dong, V. M., “Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis” (opens in new tab), Journal of the American Chemical Society, vol. 145, no. 7, pp. 3909-3914, 2023.
- Wang, M., Simon, J. C., Xu, M., Corio, S. A., Hirschi, J. S., Dong, V. M., “Copper-Catalyzed Hydroamination: Enantioselective Addition of Pyrazoles to Cyclopropenes” (opens in new tab), Journal of the American Chemical Society, vol. 145, no. 27, pp. 14573-14580, 2023.
- Slocumb, H. S., Nie, S., Dong, V. M., Yang, X., “Enantioselective Selenol-ene Using Rh-Hydride Catalysis” (opens in new tab), Journal of the American Chemical Society, vol. 144, no. 40, pp. 18246-18250, 2022.
- Warnica, J. M., Ouyang, N. Y., Dong, V. M., “Enantioselective Hydromethylation of Unfunctionalized Olefins with Copper-Hydride Catalysis” (opens in new tab), Chem Catalysis, vol. 2, no. 11, pp. 2826-2828, 2022.
- Lu A., Dong V.M., “Comparing Apples to Alkanes: Teaching Newman Projections and Conformation by Analogy” (opens in new tab), Journal of Chemical Education, vol. 99, pp. 1106-1109, 2022.
- Wang M., Lu A., Dong V.M., “13.05 - Hydroformylation: Alternatives to Rh and Syn-gas” (opens in new tab), Comprehensive Organometallic Chemistry IV Volume 1 15, vol. 13, pp. V13-V13-220, 2022.
- Chung, C. P., Parker, P. D., Dong, V. M., “Towards a, a-Disubstituted Amino Acids Containing Vicinal Stereocenters via Stereoselective Transition-Metal Catalyzed Allylation” (opens in new tab), ARKIVOC: Online Journal of Organic Chemistry, vol. 2021, 2021.
- Davison, R. T., Kuker, E. L., Dong, V. M., “Teaching Aldehydes New Tricks Using Rhodium-and Cobalt-Hydride Catalysis” (opens in new tab), Accounts of Chemical Research, vol. 54, no. 5, pp. 1236–1250, 2021.
- Davison, R. T., Parker, P. D., Hou, X., Chung, C. P., Augustine, S. A., Dong, V. M., “Enantioselective Addition of Α‐Nitroesters to Alkynes” (opens in new tab), Angewandte Chemie International Edition, vol. 133, no. 9, pp. 4649–4653, 2021.
- Nie, S., Lu, A., Kuker, E. L., Dong, V. M., “Enantioselective Hydrothiolation: Diverging Cyclopropenes through Ligand Control” (opens in new tab), Journal of the American Chemical Society, vol. 143, no. 16, pp. 6176–6184, 2021.
- Parker, P. D., Hou, X., Dong, V. M., “Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis” (opens in new tab), Journal of the American Chemical Society, vol. 143, no. 18, pp. 6724–6745, 2021.
- Jiu A.Y., Slocumb H.S., Yeung C.S., Yang X.-H., Dong V.M., “Enantioselective Addition of Pyrazoles to Dienes**” (opens in new tab), Angewandte Chemie International Edition, vol. 60, pp. 19660-19664, 2021.
Most Cited Publications
- Yeung, C. S., Dong, V. M., “Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon− Hydrogen Bonds” (opens in new tab), Chemical Reviews, vol. 111, no. 3, pp. 1215–1292, 2011.
- Zhao, X., Dimitrijevic, E., Dong, V. M., “Palladium-Catalyzed C− H Bond Functionalization with Arylsulfonyl Chlorides” (opens in new tab), Journal of the American Chemical Society, vol. 131, no. 10, pp. 3466-3467, 2009.
- Zhao, X., Yeung, C. S., Dong, V. M., “Palladium-Catalyzed Ortho-Arylation of O-Phenylcarbamates with Simple Arenes and Sodium Persulfate” (opens in new tab), Journal of the American Chemical Society, vol. 132, no. 16, pp. 5837–5844, 2010.
- Yeung, C. S., Dong, V. M., “Beyond Aresta's Complex: Ni-and Pd-Catalyzed Organozinc Coupling with CO₂” (opens in new tab), Journal of the American Chemical Society, vol. 130, no. 25, pp. 7826-7827, 2008.
- Cruz, F. A., Dong, V. M., “Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen's Amine” (opens in new tab), Journal of the American Chemical Society, vol. 139, no. 3, pp. 1029–1032, 2017.
- Li, Y., Song, D., Dong, V.M., “Palladium-catalyzed olefin dioxygenation” (opens in new tab), Journal of the American Chemical Society, vol. 130, no. 10, pp. 2916-2917, 2008.
- Phan, D. H., Kim, B., Dong, V. M., “Phthalides by Rhodium-Catalyzed Ketone Hydroacylation” (opens in new tab), Journal of the American Chemical Society, vol. 131, no. 43, pp. 15608-15609, 2009.
- Murphy, S. K., Park, J.-W., Cruz, F. A., Dong, V. M., “Rh-Catalyzed C–C Bond Cleavage by Transfer Hydroformylation” (opens in new tab), Science, vol. 347, no. 6217, pp. 56–60, 2015.
- Yeung, C. S., Zhao, X., Borduas, N., Dong, V. M., “Pd-Catalyzed Ortho-Arylation of Phenylacetamides, Benzamides, and Anilides with Simple Arenes Using Sodium Persulfate” (opens in new tab), Chemical Science, vol. 1, no. 3, pp. 331–336, 2010.
- Dong V.M., Fiedler D., Carl B., Bergman R.G., Raymond K.N., “Molecular recognition and stabilization of iminium ions in water” (opens in new tab), Journal of the American Chemical Society, vol. 128, pp. 14464-14465, 2006.
Contact Information
Website: https://sites.google.com/uci.edu/vydonggroup/home
Email: dongv@uci.edu
Phone: (949) 824-9758
Address: 4206 Natural Sciences I
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Last updated on 4/23/2026.