Daniel W. Shrey
Biography
Daniel W. Shrey, M.D., M.S., is Associate Professor of Clinical Pediatrics in the Department of Pediatrics at the University of California, Irvine, and a pediatric neurologist and epileptologist in the Division of Neurology at CHOC Children's Hospital. A physician-scientist specializing in pediatric epilepsy, Shrey focuses on developing computational biomarkers for infantile spasms and Lennox-Gastaut syndrome using electroencephalography-based functional connectivity and quantitative analysis methods. He received his M.D. from the University of Cincinnati College of Medicine and completed his pediatrics residency, child neurology residency, and clinical neurophysiology fellowship at UCLA and UC Irvine/CHOC Children's.
Shrey has served as principal investigator or co-investigator on multiple funded research projects totaling over $2.5 million, including grants from the National Institutes of Health, the Pediatric Epilepsy Research Foundation, and CHOC institutional awards. His research program examines multimodal biomarker-based predictive models for infantile spasms, high-frequency oscillations for seizure localization in epilepsy surgery, and disease evolution in Lennox-Gastaut syndrome. From 2018 to 2021, he served as Director of Neuroscience Research at CHOC and was selected for the CHOC Physician Scientist Scholars Program from 2019 to 2022.
Shrey is an elected Fellow of the American Epilepsy Society and the American Clinical Neurophysiology Society. He has authored over 35 peer-reviewed publications and numerous conference presentations on computational approaches to pediatric epilepsy. He is an active member of the Pediatric Epilepsy Research Consortium, where he has served as Infantile Spasms Interest Group Leader and currently serves on the Research and Marketing Committees. He holds board certifications in neurology with special qualifications in child neurology, epilepsy, and clinical neurophysiology with intraoperative monitoring.
Return to topEducation
- M.S. in Biomedical & Translational Science, University of California, Irvine, 2025
- M.D., University of Cincinnati College of Medicine, 2008
- B.S. in Biomedical Engineering, Northwestern University, 2004
Distinctions
- Fellow of the American Clinical Neurophysiology Society (FACNS), 2022
- Fellow of the American Epilepsy Society (FAES), 2022
- American Epilepsy Society Epilepsy Fellow Scholarship Award, 2013
- American Academy of Neurology Resident Scholarship Award, 2013
- Gold Humanism Honor Society Member, 2007
- UCLA Division of Stroke Neurology Roger Bannister Award, 2011
- UCLA Star Award of Excellence, 2010
- California Magazine Top Doctors: Top Child Neurologist, 2020
- Orange County Medical Association Physician of Excellence, 2019
Areas of Expertise
- Pediatric Epilepsy
- Infantile Spasms Biomarkers
- EEG Functional Connectivity Networks
- High Frequency Oscillations Detection
- Lennox-Gastaut Syndrome Evolution
- Surgical Outcome Prediction
- Neurophysiological Monitoring Technology
Recent Publications
- Karakas C., Warren A.E.L., Knowles J.K., Perry M.S., Caraway A., Wong-Kisiel L., Javarayee P., Olaya J., Shrey D., Karia S., Sah J., Ostendorf A.P., Tatachar P., Alexander A.L., Eschbach K., Bolton J., Reddy S.B., McCormack M.J., Singh R., Depositario-Cabacar D., et al., “Corpus Callosotomy or Focal Surgery in Children Presenting With Generalized Tonic Seizures: Findings From the Pediatric Epilepsy Research Consortium” (opens in new tab), Pediatric Neurology, vol. 178, pp. 170-177, 2026.
- Jeno M., Koop J., Gabriel M., Caraway A., Novotny E., Patrick K., Gonzalez-Giraldo E., Auguste K., Ostendorf A., McNally K., Alexander A., Berrios-Servios G., Eschbach K., Bolton J., Ailion A., Singh R., Wong-Kisiel L., Zaccariello M., Tatachar P., Duong P., et al., “Neuropsychological assessments in a large cohort of pediatric palliative epilepsy surgery patients” (opens in new tab), Epilepsy and Behavior, vol. 178, 2026.
- Berl M.M., Wagner J., Caraway A., Loblein H., Novotny E.J., Patrick K., Ostendorf A.P., Alexander A.L., Eschbach K.L., Depositario-Cabacar D.F., Vu T.-A., Oluigbo C., Karia S.R., Karakas C., Wong-Kisiel L.C., Romanowski E.F., McNamara N.A., Bolton J., Ailion A., Tatachar P., et al., “Disparities across the pediatric epilepsy surgery journey: Referral, recommendation, and completion from a national consortium” (opens in new tab), Epilepsia, vol. 67, pp. 1601-1613, 2026.
- Romero Mila B., Liu V.B., Smith R.J., Hu D.K., Benneian N.A., Hussain S.A., Steenari M., Phillips D., Adams D., Skora C., Lopour B.A., Shrey D.W., “EEG functional connectivity as a marker of evolution from infantile epileptic spasms syndrome to Lennox–Gastaut syndrome” (opens in new tab), Epilepsia, vol. 67, pp. 895-907, 2026.
- Mostaghimi S., Pinto-Orellana M.A., Green N., Shrey D.W., Miyakoshi M., Hussain S.A., Lopour B.A., “Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase–amplitude coupling” (opens in new tab), Epilepsia Open, 2026.
- Briscoe C., Katyayan A., Harini C., Hussain S.A., Bhalla S., Singh A., Donatelli S., Sandoval Karamian A.G., Samanta D., Sirsi D., Catenaccio E., Planchart Ferretto M.A., Thio L.L., Hunter S.E., Spriha P., Rao C.K., Bhatia S., Erdemir G., Shrey D.W., Numis A.L., “Treatment Practices for Infantile Epileptic Spasms Syndrome: Consensus and Variation in Major Pediatric Epilepsy Centers” (opens in new tab), Pediatric Neurology, vol. 174, pp. 46-53, 2026.
- Jung B.C., Ho V., Abata J., Hanna S., Qing K., Deng D., Vadera S., Mnatsakanyan L., Sazgar M., King-Stephens D., Shrey D.W., Lopour B.A., “Stronger pre-surgical functional connectivity networks are associated with improved surgical outcome in temporal lobe epilepsy” (opens in new tab), Clinical Neurophysiology, vol. 179, 2025.
- Samanta D., Newell G., Caraway A.R., Brock E., Albert G.W., Novotny E.J., Depositario Cabacar D.F., Oluigbo C.O., Gaillard W.D., Tatachar P., Bolton J.B., Wong-Kisiel L., Romanowski E.F., Mcnamara N.A., Eschbach K., Alexander A.L., Auguste K.I., Gonzalez-Giraldo E., Bernardo D., Ostendorf A.P., et al., “Factors Associated With More Medication Trials Before Surgical Evaluation and Postsurgical Outcomes in Pediatric Drug-Resistant Epilepsy” (opens in new tab), Neurology, vol. 105, 2025.
- Mendoza T, Trevino CL, Shrey DW, Lin JJ, Gen-Gupta I, Lopour BA, “Optimizing automated detection of high frequency oscillations using visual markings does not improve SOZ localization” (opens in new tab), Clinical Neurophysiology, vol. 164, pp. 30-39, 2024.
- Sindhu RS, Ombao HC, Riba A, Phillips D, Olaya J, Shrey DW, Lopour BA, “Electrode surface area impacts measurement of High Frequency Oscillations in human intracranial EEG” (opens in new tab), IEEE Transactions on Biomedical Engineering, vol. 71, pp. 3283-3292, 2024.
- Charuta Joshi, Rani Singh, Gang Liu, Cemal Karakas, Michael Ciliberto, Krista Eschbach, M. Scott Perry, Daniel Shrey, Tricia Morphew, Adam P. Ostendorf, Shilpa B. Reddy, Michael J. McCormack, Samir Karia, Shrishti Nangia, Lily Wong-Kisiel, the PERC Surgery Workgroup, “Determinants of successful ictal SPECT in pediatric presurgical evaluation: Findings from the PERC surgery database project” (opens in new tab), Epilepsia Open, vol. 9, no. 4, pp. 1467-1479, 2024.
Most Cited Publications
- Shrey DW, Griesbach GS, Giza CC, “The pathophysiology of concussions in youth” (opens in new tab), Physical Medicine and Rehabilitation Clinics of North America, vol. 22, no. 4, pp. 577-vii, 2011.
- Shrey DW, Kim McManus O, Rajaraman R, Ombao H, Hussain SA, Lopour BA, “Strength and stability of EEG functional connectivity predict treatment response in infants with epileptic spasms” (opens in new tab), Clinical Neurophysiology, vol. 129, no. 10, pp. 2137-2148, 2018.
- Romero Mila B, Sindhu KR, Mytinger JR, Shrey DW, Lopour BA, “EEG biomarkers for the diagnosis and treatment of infantile spasms” (opens in new tab), Frontiers in Neurology, vol. 13, pp. 960454, 2022.
- Armour EA, Yiu AJ, Shrey DW, Reddy SB, “Underrepresented populations in pediatric epilepsy surgery” (opens in new tab), Seminars in Pediatric Neurology, vol. 39, pp. 100916, 2021.
- Hu DK, Mower A, Shrey DW, Lopour BA, “Effect of interictal epileptiform discharges on EEG-based functional connectivity networks” (opens in new tab), Clinical Neurophysiology, vol. 131, pp. 1087-1098, 2020.
This profile was created with the help of AI.
Last updated on 6/4/2026.