Eric W. Doran
Biography
Eric W. Doran, M.S., is a Specialist in the Down Syndrome Program in the Department of Pediatrics at the University of California, Irvine. He received his M.S. in Genetic Counseling from the University of California, Irvine in 2003, where his thesis examined cognitive and behavioral profiles in individuals with Down syndrome and autism. Doran has been with the UCI Down Syndrome Program since 2000, initially as a graduate student researcher and coordinator, and has held his current position since 2003.
Doran has been a co-investigator on multiple federally funded research projects examining Alzheimer's disease in adults with Down syndrome, including the Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS) and studies investigating biomarkers and cognitive decline in this population. He has contributed to research on the relationship between APP gene dosage and Alzheimer's disease development, including a study of partial trisomy 21 that examined the role of APP in disease pathology. His work has also addressed the use of plasma and cerebrospinal fluid biomarkers, neuroimaging, and metabolic markers in understanding dementia progression in Down syndrome.
Doran has authored or co-authored over 70 peer-reviewed publications in journals including Archives of Neurology, Journal of Alzheimer's Disease, Lancet Neurology, and Acta Neuropathologica. He has served on the Advisory Board of the UCI Graduate Program in Genetic Counseling since 2019 and has been a thesis mentor for genetic counseling students since 2005. Doran is certified as a Clinical Research Professional by the Society of Clinical Research Associates and has been active in community service, including founding and facilitating support groups for families affected by Down syndrome and Alzheimer's disease and serving on the Board of Directors of the Down Syndrome Association of Orange County.
Return to topEducation
- B.A. in General Biology, University of California, San Diego, 1989
- M.S. in Genetic Counseling, University of California, Irvine, 2003
Areas of Expertise
- Down Syndrome Neurodevelopment
- Alzheimer Disease Biomarkers
- Cognitive Decline Trajectories
- Dementia Neuropathology
- Cerebral Amyloid Deposition
- Plasma Metabolite Profiling
- Clinical Trial Coordination
Recent Publications
- Lott IT, Kirby KA, Doran E, Grill JD, “Research attitudes in families of individuals with Down syndrome: importance for clinical trials” (opens in new tab), Alzheimer S Research and Therapy, vol. 14, no. 1, pp. 176, 2022.
- Kumar A., Doran E., Martini A.C., Head E., Kirby K., “CAA and related co-morbidities in Down syndrome and Alzheimer disease” (opens in new tab), Alzheimer S Dementia the Journal of the Alzheimer S Association, vol. 17, pp. e058726, 2021.
Most Cited Publications
- Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT, “Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP” (opens in new tab), Journal of Alzheimer S Disease, vol. 56, no. 2, pp. 459-470, 2017.
- Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL, “Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation” (opens in new tab), American Journal of Medical Genetics Part A, vol. 155, pp. 1939-1948, 2011.
- Lott IT, Head E, Doran E, Busciglio J, “Beta Amyloid, Oxidative Stress and Down Syndrome” (opens in new tab), Current Alzheimer Research, vol. 3, no. 5, pp. 521-8, 2006.
- Lott IT, Doran E, Nguyen VQ, Tournay A, Movsesyan N, Gillen DL, “Down syndrome and dementia: seizures and cognitive decline” (opens in new tab), Journal of Alzheimer S Disease, vol. 29, no. 1, pp. 177-85, 2012.
- Lott IT, Doran E, Osann K, Nelson LD, “Down Syndrome and Alzheimer Disease: Response to Donepezil” (opens in new tab), Archives of Neurology, vol. 59, pp. 1133-1136, 2002.
- Head E, Lott IT, Patterson D, Doran E, Haier RJ, “Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology” (opens in new tab), Journal of Alzheimer's Disease, vol. 11, no. 1, pp. 61-76, 2007.
- Head E, Doran E, Nistor M, Hill MA, Schmitt F, Haier R, Lott IT, “Plasma Aβ as a Function of Age, Level of Intellectual Disability and Presence of Dementia in Down syndrome” (opens in new tab), Journal of Alzheimer S Disease, vol. 23, no. 3, pp. 399-409, 2011.
- Henson RL, Doran E, Christian BT, Handen BL, Klunk WE, Lai F, Lee JH, Rosas HD, Schupf N, Zaman SH, Lott IT, Fagan AM, “Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome” (opens in new tab), Alzheimer S and Dementia Diagnosis Assessment and Disease Monitoring, vol. 12, no. 1, pp. e12057, 2020.
- Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M, “Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease” (opens in new tab), Developmental Neurobiology, vol. 79, no. 7, pp. 622-638, 2019.
- Walsh DM, Doran E, Silverman W, Tournay A, Movsesyan N, Lott IT, “Rapid assessment of cognitive function in Down syndrome across intellectual level and dementia status” (opens in new tab), Journal of Intellectual Disability Research, vol. 59, pp. 1071-1079, 2015.
Contact Information
Email: edoran@uci.edu
Phone: (714) 456-8443
Address: 3800 W. Chapman Ave, Suite 2200, Irvine, CA 92697-4482
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Last updated on 2/20/2026.