Olivia L. Lee
Health Sciences Professor, Department of Ophthalmology, School of Medicine, University of California, Irvine
Faculty, Cornea and Uveitis Divisions, Gavin Herbert Eye Institute, Department of Ophthalmology, School of Medicine, University of California, Irvine
Biography
Olivia L. Lee, M.D., is Health Sciences Professor and Director of the Anterior Segment Imaging Laboratory at the Gavin Herbert Eye Institute, Department of Ophthalmology, School of Medicine, University of California, Irvine. She also serves as Program Director of the Cornea Research Fellowship Program and has been an attending ophthalmologist at the Tibor Rubin VA Medical Center in Long Beach. Lee received her M.D. from Baylor College of Medicine through the Rice/Baylor Medical Scholars Program and completed fellowships in cornea, external disease, and refractive surgery at the Jules Stein Eye Institute, UCLA, and in uveitis and ocular immunology at the New York Eye and Ear Infirmary.
Lee's research focuses on anterior segment imaging, particularly the application of in vivo confocal microscopy and specular microscopy to evaluate corneal and ocular surface diseases. She has served as principal investigator on numerous funded studies examining ocular graft-versus-host disease, infectious keratitis, and pterygium pathogenesis, including clinical trials for novel therapeutics. Her work has resulted in over 30 peer-reviewed publications in journals such as Cornea, Archives of Ophthalmology, and Translational Vision Science & Technology. Lee has mentored more than 60 medical students, residents, and postdoctoral fellows, and has directed cornea fellowship programs at UCLA and UC Irvine.
Lee has presented over 190 invited lectures nationally and internationally and has received multiple best paper awards at the American Society of Cataract and Refractive Surgery annual meetings. She serves on numerous professional committees, including the American Academy of Ophthalmology Online Education Committee and the American Society of Cataract and Refractive Surgery Cornea Clinical Committee. Lee is an active member of the Cornea Society, the Association for Research in Vision and Ophthalmology, and the Foster Ocular Immunology Society. She has contributed to international volunteer medical missions in Indonesia, China, and Mongolia, providing surgical training and patient care in underserved regions.
Return to topEducation
- B.A. in Psychology, Rice University, 2001
- M.D., Baylor College of Medicine, 2005
Distinctions
- The White House Presidential Scholars Program, 1998
- Howard Hughes Medical Institute/NIH Internship Awardee, 1998
- LEO Award, AAO, 2022
- Faculty Teaching Award, UCI Department of Ophthalmology, 2022
- 20/20 Pilot Research Award, Gavin Herbert Eye Institute, 2023
- Film Festival Winner: Category New Producer, ASCRS Symposium, 2012
- Achievement Award, AAO, 2018
- Louise J. Girard Award for Ophthalmic Research, 2009
- Outstanding Scholastic Achievement in Biomedical Science, American Heart Association, 1996
- Southern California Super Doctors, 2022-2025
- Pasadena Magazine Top Doctors, 2012-2016
Areas of Expertise
- Cornea and Uveitis
- Confocal Microscopy Imaging
- Ocular Graft-Versus-Host Disease
- Infectious Keratitis Diagnosis
- Machine Learning Corneal Analysis
- Neurotrophic Keratopathy Treatment
- Pterygium Pathogenesis
Recent Publications
- Yang CD, Carbonell BAC, Hussey VM, Herekar AA, Kim CK, Morcos DM, Smith AK, Fox AR, Mosaed S, Lin KY, Lee OL, “Decoding Corneal Endothelial Loss from Glaucoma Treatment : A Case-control Stratification Analysis” (opens in new tab), Journal of Current Glaucoma Practice, vol. 19, no. 2, pp. 68-74, 2025.
- Crook T, Khosravi P, Tang J, Zhou P, Nazarali S, Lee OL, “Can AI replace the Uveitis Specialist? The Role of LLM's in Uveitis Diagnosis and Treatment”, 2025. Presented at Sonoma Eye 2025, San Diego, CA, March 23, 2025.
- Carbonell BA, Huang W, Lee OL, “Recombinant Human Nerve Growth Factor as Adjunctive Perioperative Therapy in Eyes with Neurotrophic Keratitis Undergoing Corneal Surgery”, 2025. Presented at Sonoma Eye 2025, San Diego, CA, March 23, 2025.
- Unno N, Milhomens AJ, Karslioglu M, Kim C, Giraldo J, Guo S, Tang J, Lien N, Tran A, Elghazali FA, Lee OL, “Longitudinal Evaluation of Recombinant Human Nerve Growth Factor for Neurotrophic Keratopathy”, 2025. Presented at Sonoma Eye 2025, San Diego, CA, March 23, 2025.
- Carbonell B, Milohomens Filho JP, Giraldo JR, Rao N, Ganasi RS, Lim J, Kim C, Karlioglu MZ, Fox A, Lin KY, Lee OL, “Evaluation of Corneal Nerves and Epithelial Cell Changed Induced by Topical Antiglaucoma Agents: An in Vivo Confocal Microscopy Study”, 2025. Presented at ASCRS Annual Meeting, Los Angeles, CA, April 27, 2025.
- Carbonell B, Milohomens Filho JP, Giraldo JR, Lin KY, Smith A, Fox A, Mosaed S, Lee OL, “Analysis of Topical Anti-Inflammatory Therapy on Corneal Dendritic Cell Density in Treated Glaucomatous Eyes Via In Vivo Confocal Microscopy”, 2025. Presented at ASCRS Annual Meeting, Los Angeles, CA, April 27, 2025.
- Guo S, Shooshani TS, Milohomens Filho JP, Kim C, Giraldo JR, Karlioglu MZ, Lee OL, “Correlation of Corneal Nerve Density and Corneal Sensation in Neurotrophic Keratitis Treated with Rhngf”, 2025. Presented at ASCRS Annual Meeting, Los Angeles, CA, April 27, 2025.
- Lien N, Crook T, Tang J, Lee OL, “An automated ensemble deep learning approach to predicting epithelial cell counts in corneal images”, 2025. Presented at Sonoma Eye 2025, San Diego, CA, March 22, 2025.
- Kim CK, Mekhail JT, Morcos DM, Yang CD, Kedhar SR, Kim C, Del Valle Estopinal M, Lee OL, “Three cases of recalcitrant Paecilomyces keratitis in Southern California within a short period” (opens in new tab), Journal of Ophthalmic Inflammation and Infection, vol. 14, no. 1, pp. 1, 2024.
- Kim CK, Karslioglu MZ, Zhao SH, Lee OL, “Infectious Keratitis in Patients Over 65: A Review on Treatment and Preserving Eyesight” (opens in new tab), Clinical Interventions in Aging, vol. 19, pp. 1393-1405, 2024.
- Carbonell BA, Kim C, Milhomens JAP, Fox A, Lin KY, Lee OL, “Effect of Topical Antiglaucoma Therapy on Corneal Dendritic Cell Density Using In Vivo Confocal Microscopy”, 2024. Presented at ASCRS Annual Meeting, Boston, MA, April 6, 2024.
- Khosravi P, Shooshani T, Pooladzandi O, Karslioglu MZ, Kim C, Lee OL, “Interpretable Deep Learning Models for Distinguishing between HSV and VZV Keratitis on In Vivo Confocal Microscopy”, 2024. Presented at ASCRS Annual Meeting, Boston, MA, April 7, 2024.
- Shooshani T, Shosravi P, Poolandzandi O, Kim C, Karslioglu MZ, Lee OL, “Deep Learning for Acanthamoeba Cyst Identification on In Vivo Confocal Microscopy”, 2024. Presented at ASCRS Annual Meeting, Boston, MA, April 7, 2024.
- Karlsioglu MZ, Kim C, Wade M, Lee OL, “The efficacy of autologous serum drops in the treatment of ocular surface diseases”, 2024. Presented at ASCRS Annual meeting, Boston, MA, April 2024.
- Unno Y, Milhomens JA, Kim C, Karslioglu M, Lee OL, “Longitudinal Assessment of Epithelial Cell Densities in Neurotrophic Keratitis Patients Treated with Recombinant Human Nerve Growth Factor in vivo via Confocal Microscopy”, 2024. Presented at Imaging in the Eye Conference, ARVO, Seattle, WA, May 4, 2024.
- Shooshani T, Khosravi P, Poolandzandi Omead, Kim C, Karslioglu M, Lee OL, “Machine Learning to Distinguish Etiology of Infectious Keratitis on In Vivo Confocal Microscopy”, 2024. Presented at Imaging in the Eye Conference, ARVO, Seattle, WA, May 4, 2024.
- Morcos D, del Valle Estopinal M, Lee OL, “Acute Calcific Band Keratopathy After the Use of Cenegermin for Neurotrophic Keratitis: A Case Series”, 2024. Presented at ARVO Annual Meeting, Seattle, WA, May 5, 2024.
- Low LN, Giraldo J, Lien N, Karslioglu M, Milhomens JAP, Kim C, Lee OL, “Comparative Analysis of Epithelial Defect Surface Area Quantification: A Validation Study of Semiautomated and Manual Grading Methods”, 2024. Presented at ARVO Annual Meeting, Seattle, WA, May 6, 2024.
- Shooshani T, Khosravi P, Kim C, Karslioglu M, del Valle Estopinal M, Lee OL, “Degenerated Acanthamoeba cysts demonstrated on confocal microscopy: A case series”, 2024. Presented at ARVO Annual Meeting, Seattle, WA, May 7, 2024.
- Carbonell Blaze, Lee OL, “Effect of Topical Antiglaucoma Therapy on Corneal Dendritic Cell Density Using In Vivo Confocal Microscopy”, 2024. Presented at WIO Annual Meeting, Carlsbad, CA, August 2024.
Most Cited Publications
- Tepelus TC, Chiu GB, Huang J, Huang P, Sadda SR, Irvine J, Lee OL, “Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study” (opens in new tab), Graefe S Archive for Clinical and Experimental Ophthalmology, vol. 255, no. 9, pp. 1771-1778, 2017.
- Abdelfattah NS, Dastiridou A, Sadda S, Lee OL, “Noninvasive Imaging of Tear Film Dynamics in Eyes with Ocular Surface Disease” (opens in new tab), Cornea, vol. 34 Suppl 10, pp. S48-52, 2015.
- Wang YE, Tepelus TC, Vickers LA, Baghdasaryan E, Gui W, Huang P, Irvine JA, Hsu HY, Lee OL, “Role of In Vivo Confocal Microscopy in the Diagnosis of Infectious Keratitis” (opens in new tab), International Ophthalmology, vol. 39, no. 12, pp. 2865-2874, 2019.
- Wiaux C, Baghdasaryan E, Lee OL, Deng SX, Aldave AJ, “Outcomes after Descemet stripping endothelial keratoplasty in glaucoma patients with previous trabeculectomy and tube shunt implantation” (opens in new tab), Cornea, vol. 30, no. 12, pp. 1304-11, 2011.
- Tepelus TC, Chiu G, Maram J, Chopra V, Sadda SR, Lee OL, “Corneal features in ocular graft-versus-host disease by in vivo confocal microscopy” (opens in new tab), Graefe S Archive for Clinical and Experimental Ophthalmology, vol. 255, no. 12, pp. 2389-2397, 2017.
- Lee OL, Tepelus TC, Huang J, Irvine AG, Irvine C, Chiu GB, Sadda SR, “Evaluation of the corneal epithelium in non-Sjögren's and Sjögren's dry eyes: an in vivo confocal microscopy study using HRT III RCM” (opens in new tab), BMC Ophthalmology, vol. 18, no. 1, pp. 309, 2018.
- Huang J, Maram J, Modak C, Sadda SR, Chopra V, Lee OL, “Comparison of non-contact specular and confocal microscopy for the evaluation of the corneal endothelium” (opens in new tab), Eye and Contact Lens, vol. 44, pp. S144-S150, 2018.
- Lee OL, Baghdasaryan E, Tepelus TC, Marion KM, Huang J, Huang P, Sadda SR, “Analysis of ocular inflammation in anterior chamber-involving uveitis using swept-source anterior segment OCT” (opens in new tab), International Ophthalmology, vol. 39, pp. 1793-1801, 2019. Presented at UCLA/American Uveitis Society Workship on Objective Measures of Intraocular Inflammation for Use in Clinical Trials, March 22, 2019.
- Huang P, Tepelus T, Vickers LA, Baghdasaryan E, Huang J, Irvine JA, Hsu HY, Sadda S, Lee OL, “Quantitative Analysis of Depth, Distribution, and Density of Cysts in Acanthamoeba Keratitis Using Confocal Microscopy” (opens in new tab), Cornea, vol. 36, no. 8, pp. 927-932, 2017.
- Huang J, Maram J, Tepelus TC, Modak C, Marion K, Sadda SR, Chopra V, Lee OL, “Comparison of manual & automated analysis methods for corneal endothelial cell density measurements by specular microscopy” (opens in new tab), Journal of Optometry, vol. 11, no. 3, pp. 182-191, 2017.
Contact Information
Email: leeol@uci.edu
Phone: (949) 824-2020
Address: 850 Health Sciences Road, Irvine, CA 92697-4375
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Last updated on 3/12/2026.