Maki Yamamoto
Biography
Maki Yamamoto, M.D., FACS, is Vice Chair of Outpatient Clinical Affairs and Health Sciences Associate Clinical Professor in the Department of Surgery at the University of California, Irvine Medical Center, where she also serves as Associate Director of the Melanoma Center and Associate Residency Program Director. She is a staff surgeon at the Long Beach Veterans Affairs Hospital. Yamamoto received her M.D. from New York Medical College and completed a fellowship in Surgical Oncology at H. Lee Moffitt Cancer Center and Research Institute. She is board certified in both Surgery and Complex General Surgical Oncology.
Yamamoto's clinical and research focus centers on melanoma and soft tissue sarcoma. Her work has examined sentinel lymph node biopsy techniques, surgical margins in melanoma, and the use of gene expression profiling to guide treatment decisions. She has authored over 40 peer-reviewed publications and contributed book chapters on melanoma epidemiology, biopsy techniques, and surgical management. Her research has been presented at national and international meetings including the Society of Surgical Oncology, American College of Surgeons, and World Congress of Lymphology.
Yamamoto serves on multiple institutional committees at UC Irvine Health, including as Co-chair of the Perioperative Quality and Patient Safety Committee, Co-chair of the Cutaneous Tumor Board and Sarcoma Tumor Board, and Chair of the Clinical Competency Committee. She is a member of the Graduate Medical Education Committee and Medical Executive Committee. She serves on the American College of Surgeons Committee on Applicants for District 5 and is a member of the Association of Program Directors in Surgery, where she has mentored multiple Associate Program Directors from other institutions.
Return to topEducation
- B.A. with Honors in Molecular and Cell Biology/Immunology, University of California, Berkeley, 2000
- M.D., New York Medical College, 2004
Distinctions
- Fellow in the American College of Surgeons, 2016
- World Congress of Lymphology Young Investigator Award, 2015
- National Merit Scholar, 1996
- Department of Surgery, Chairman's Award (Outstanding Chief Resident), University of California, Irvine Medical Center, 2011
- William Cheney M.D. Award (Outstanding Resident), Long Beach Memorial Hospital, 2010
- Golden Key National Honor Society, 1996
- The Surgical Society of New York Medical College Award, 2004
- Surgical Intensive Care Unit Intern of the Year, Long Beach Veterans Affairs Hospital, 2005
- Orange County Medical Association Physician of Excellence, 2020-2023
- High School Valedictorian, Mission San Jose High School, 1996
Areas of Expertise
- Surgical Oncology
- Melanoma Sentinel Node Biopsy
- Hepatobiliary Pancreatic Surgery
- Neoadjuvant Chemotherapy Response
- Immunotherapy Checkpoint Inhibitors
- Merkel Cell Carcinoma
- Gastric Cancer Surgical Management
Recent Publications
- Li Y., Linden K.G., Jakowatz J.G., Yamamoto M., Tran T.B., “Identifying high-risk subtypes and risk factors for recurrence in Merkel cell carcinoma: A single-institution retrospective study” (opens in new tab), Journal of the American Academy of Dermatology, vol. 94, pp. 984-986, 2026.
- Barnachea D., Yamamoto M., Banker R., Ren D., Lee B., “Novel Histopathologic Features of Extramammary Paget's Disease in Metastatic Primary Cutaneous Apocrine Carcinoma to the Esophagus” (opens in new tab), Journal of Cutaneous Pathology, vol. 52, pp. 754-758, 2025.
- Guenther J.M., Ward A., Martin B.J., Cripe M., Beard T., Wisco O., Sharma R., Leong S.P., Essner R., Clark J.I., Hamner J., Sickle-Santanello B., Yamamoto M., “A Prospective, Multicenter Analysis of Recurrence-Free Survival After Sentinel Lymph Node Biopsy Decisions Influenced by the 31-GEP” (opens in new tab), Cancer Medicine, vol. 14, 2025.
- COVIDSurg Collaborative, GlobalSurg Collaborative, “SARS-CoV-2 infection and venothromboembolism after surgery: an international prospective cohort study”, Anaesthesia, vol. 77, no. 1, pp. 28-39, 2022.
- Shwe S, Yamamoto M, Linden KG, Lee BA, “Tumoral Melanosis and Separate Granulomatous Inflammation due to Talimogene Laherparepvec” (opens in new tab), American Journal of Dermatopathology, vol. 44, no. 7, pp. 541-543, 2022.
- Cinar P, Yamamoto M, Rugo HS, “Planning for post-pandemic cancer care delivery: Recovery or opportunity for redesign?” (opens in new tab), CA Cancer Journal for Clinicians, vol. 71, no. 1, pp. 34-46, 2021.
- COVIDSurg Collaborative, GlobalSurg Collaborative, “SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study”, British Journal of Surgery, 2021.
- COVIDSurg Collaborative, GlobalSurg Collaborative, “Timing of Surgery Following SARS-CoV-2 infection: an international prospective cohort study”, Anaesthesia, vol. 76, no. 6, pp. 748-758, 2021.
- COVIDSurg Collaborative, GlobalSurg Collaborative, “Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study”, Anaesthesia, vol. 76, no. 110, pp. 1454-1464, 2021.
- Mailey BA, Alrahawan G, Brown A, Yamamoto M, Hassanein AH, “Sentinel Lymph Node Biopsy, Lymph Node Dissection and Lymphedema Management Options in Melanoma” (opens in new tab), Clinics in Plastic Surgery, vol. 48, no. 4, pp. 607-616, 2021.
Most Cited Publications
- Yamamoto M, Rashid OM, Wong J, “Surgical Management of Gastric Cancer: the East vs West perspective” (opens in new tab), Journal of Gastrointestinal Oncology, vol. 6, no. 1, pp. 79-88, 2015.
- Yamamoto M, Hayashi MS, Nguyen NT, “Use of Seamguard to prevent pancreatic leak following distal pancreatectomy” (opens in new tab), Archives of Surgery, vol. 144, pp. 894-9, 2009.
- Yamamoto M, Weber JM, Karl RC, Meredith KL, “Minimally invasive surgery for esophageal cancer: Review of the literature and the institutional experience” (opens in new tab), Cancer Control, vol. 20, no. 2, pp. 130-137, 2013.
- Yamamoto M, Fisher KJ, Wong JY, “Sentinel Lymph Node Biopsy is Indicated for Patients with Thick Clinically Lymph Node-Negative Melanoma” (opens in new tab), Cancer, vol. 121, no. 10, pp. 1628-36, 2015.
- Hsiang DJ, Yamamoto M, Mehta RS, “Predicting nodal status using dynamic contrast-enhanced magnetic resonance imaging in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy with and without sequential trastuzumab” (opens in new tab), Archives of Surgery, vol. 142, pp. 855-61, 2007.
- Doepker MP, Yamamoto M, Applebaum MA, Patel NU, Montilla-Soler JM, Sarnaik AA, Cruse WC, Sondak VK, Zager JZ, “Comparison of Single-Photon Emission Computed Tomography (SPECT/CT) and Conventional Planar Lymphoscinitgraphy for Sentinel Node Localization in Patients with Cutaneous Malignancies” (opens in new tab), Annals of Surgical Oncology, vol. 24, no. 2, pp. 355-361, 2017.
- Wiseman JE, Yamamoto M, Nguyen TD, “Cystic pancreatic neoplasm in pregnancy: a case report and review of the literature” (opens in new tab), Archives of Surgery, vol. 143, pp. 84-6, 2008.
- Yamamoto M, Sickle-Santanello B, Beard T, Essner R, Martin B, Bailey CN, Guenther JM, “The 31-gene expression profile test informs sentinel lymph node biopsy decisions in patient with cutaneous melanoma: results of a prospective, multicenter study” (opens in new tab), Current Medical Research and Opinion, vol. 39, no. 3, pp. 417-423, 2023.
Contact Information
Email: maki.yamamoto@uci.edu
Phone: (714) 456-6847
Address: 333 City Blvd. West, Orange, CA 92868. Suite 1600
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Last updated on 5/19/2026.