Angela Myers
Health Sciences Associate Clinical Professor, Department of Pediatrics, Division of Genetics and Genomic Medicine
Biography
Angela Myers, M.D., is a Health Sciences Associate Clinical Professor and Clinical Geneticist in the Department of Pediatrics at the University of California, Irvine. She received her medical degree from Colegio Mayor de Nuestra Señora del Rosario in Bogotá, Colombia, and completed a Medical Genetics Residency and Medical Biochemical Genetics Fellowship at Stanford University School of Medicine. Myers is board-certified by the American Board of Medical Genetics and the American Board of Family Medicine.
Before entering clinical genetics, Myers spent nearly a decade in molecular diagnostics research and development. As a Principal Scientist at Roche Molecular Systems, she led the development of multiplex PCR and allele-specific oligonucleotide hybridization kits for detecting CFTR mutations, including the LINEAR ARRAY CF-Gold assay. At Applied Biosystems, she contributed to the development of the ViroSeq HIV-1 genotyping system. Her work resulted in multiple patents for HIV sequencing and genotyping methods. She has also collaborated on international research projects studying genetic diseases including Duchenne Muscular Dystrophy, Cystic Fibrosis, and Hemophilia A across Latin America.
Myers's clinical and research focus includes metabolic disorders, RASopathies, and rare genetic syndromes. Her publications address perinatal features of Noonan syndrome and related conditions, respiratory complications in Costello syndrome, and novel genetic discoveries including loss-of-function mutations in FRRS1L and FOXP1 haploinsufficiency. She teaches medical genetics to pediatric residents and fellows at UC Irvine, presenting on topics including amino acid disorders, organic acid disorders, and mitochondrial and peroxisomal diseases.
Return to topAreas of Expertise
- Medical Genetics
- Cystic Fibrosis Transmembrane Regulator
- RASopathies Perinatal Presentation
- Lysosomal Storage Disorders
- Warsaw Syndrome Multi-Omics
- Inborn Errors of Metabolism
- Chromosomal Mosaicism Array Analysis
Recent Publications
- DuBois M., Dixon K., Sherlaw-Sturrock C., Shen Y., Probst F., Clarke L., Lyalin D., Shuman C., Jones S., Boerkoel C., Stewart G.S., Richmond P., Myers A., “Identification of a Non-Coding Causative Variant Underlying Warsaw Breakage Syndrome Using Long-Read Based Genomic Sequencing and Transcriptome Analysis” (opens in new tab), American Journal of Medical Genetics Part A, vol. 200, pp. 432-437, 2026.
- Schaller A, Myers A, Khan S, Joshi A, Rodriguez V, Maher G, “Case 4: Thrombocytopenia and Hematochezia in an Infant”, Pediatr Rev, vol. 40, no. 5, pp. 254-255, 2019.
- Scott A, Myers A, Enns GM, Cowan TM, “Improvement of Redox Potential Following Liver Transplantation in MMA Patients”, 2017. Presented at American College of Medical Genetics Annual Clinical Genetics Meeting, Vancouver, BC, CA.
- Gomez-Ospina N, Kuo C, Ananth AL, Myers A, Brennan M-L, Stevenson DA, Bernstein JA, Hudgins L, “Respiratory System Involvement in Costello Syndrome” (opens in new tab), American journal of medical genetics Part A, vol. 170, no. 7, pp. 1849-1857, 2016.
- Snijders Blok L, Madsen E, Juusola J, Gilissen C, Baralle D, Reijnders MR, Venselaar H, Helsmoortel C, Cho MT, Hoischen A, Vissers LE, Koemans TS, Wissink-Lindhout W, Eichler EE, Romano C, Van Esch H, Stumpel C, Vreeburg M, Smeets E, Oberndorff K, et al., “Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability in Gender-Specific Effect on Wnt Signaling”, Am J Hum Genet, vol. 97, no. 2, pp. 343-352, 2015.
- Salih MA, Seidahmed MZ, El Khashab HY, Hamad MH, Bosley TM, Burn S, Myers A, Landsverk ML, Crotwell PL, Bilguvar K, Mane S, Kruer MC, “Mutation in GM2a Leads to a Progressive Choreadementia Syndrome”, Tremor Other Hyperkinet Mov (N.Y.), vol. 5, pp. 306-306, 2015.
- Torbert N, Reuter S, Myers A, De Berg K, Crotwell PL, Flanagan JD, “Bowen-Conradi Syndrome: a trisomy 18-like autosomal recessive disorder common in Hutterites”, South Dakota Medicine the Journal of the South Dakota State Medical Association, vol. 68, no. 2, pp. 65-7, 69, 2015.
- Flanagan JD, Reuter S, Crotwell PL, Myers A, De Berg K, “A Hutterite condition that mimics Bowen-Conradi syndrome”, South Dakota Medicine the Journal of the South Dakota State Medical Association, vol. 68, no. 3, pp. 101-103, 2015.
- Kaercher K, Myers A, Davis-Keppen L, “A Case Report of an Individual with Noonan-Cardiofaciocutaneous-Costello Syndrome Spectrum with a KRAS mutation”, 2014. Presented at American College of Medical Genetics Annual Clinical Genetics Meeting, Nashville, Tennessee.
- Kaercher K, Myers A, Knight Johnson K, Davis-Keppen L, “Broad Thumbs and Broad Toes: A long Standing Clinical Diagnosis of Rubinstein Taybi Syndrome Molecularly Confirmed”, 2014. Presented at American College of Medical Genetics Annual Clinical Genetics Meeting, Nashville, Tennessee.
- Myers A, Brennan ML, Hudgins L, “Pulmonary Disease; a Rare Complication of Costello Syndrome?”, 2012. Presented at Northern Clinical Genetics Exchange 13th Annual Meeting, Oakland, California.
- Myers A, Bernstein JA, Lopez G, Hudgins L, “46,XY disorder of sex development: report of a family with an apparently novel X-linked form update”, 2012. Presented at American College of Medical Genetics Annual Clinical Genetics Meeting, Charlotte, North Carolina.
- Myers A, Bernstein JA, Cherry A, Manning MA, “Chromosomal Mosaicism Identified by Array Comparative Genomic Hybridization: A Case of Tetrasomy 12p”, 2012. Presented at Western Society for Pediatric Research Annual Meeting, Carmel, California.
- Myers A, Hintz S, Homeyer M, Manning MA, Farrelly E, Fisher J, Curry C, Hudgins L, “Perinatal Presentation of the RASopathies”, 2011. Presented at 32nd annual David W. Smith Workshop on Morphogenesis and Malformations, Lake Arrowhead, California.
- Johnston-Dow LA, Demeter L, White CB, Song K, Kohlenberger R, Conrad M, Myers A, “Methods for HIV sequencing and genotyping”, 2005. Patent No. U.S. Patent Application Publication US 2005/0003350 A1.
- Myers A, Wang L, Boppuri L, Nolley J, Macek Jr. M, “Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene Mutation Detection Made Easy by the LINEAR ARRAY™ Technology”, 2003.
Most Cited Publications
- Myers A, Bernstein JA, Brennan ML, Curry C, Esplin ED, Fisher J, Homeyer M, Manning MA, Muller EA, Niemi AK, Seaver LH, Hintz SR, Hudgins L, “Perinatal features of the RASopathies: Noonan syndrome, Cardiofaciocutaneous syndrome and Costello syndrome” (opens in new tab), American Journal of Medical Genetics Part A, vol. 164A, no. 11, pp. 2814-2821, 2014.
- Bekheirnia M.R., Bekheirnia N., Bainbridge M.N., Gu S., Akdemir Z.H.C., Gambin T., Janzen N.K., Jhangiani S.N., Muzny D.M., Michael M., Brewer E.D., Elenberg E., Kale A.S., Riley A.A., Swartz S.J., Scott D.A., Yang Y., Srivaths P.R., Wenderfer S.E., Bodurtha J., et al., “Whole-exome sequencing in the molecular diagnosis of individuals with congenital anomalies of the kidney and urinary tract and identification of a new causative gene” (opens in new tab), Genetics in Medicine, vol. 19, pp. 412-420, 2017.
- Madeo M, Stewart M, Sun Y, Sahir N, Wiethoff S, Chandrasekar I, Yarrow A, Rosenfeld JA, Yang Y, Cordeiro D, McCormick EM, Muraresku CC, Jepperson TN, McBeth LJ, Seidahmed MZ, El Khashab HY, Hamad M, Azzedine H, Clark K, Corrochano S, et al., “Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy” (opens in new tab), American Journal of Human Genetics, vol. 98, no. 6, pp. 1249-1255, 2016.
- Levin M.D., Saitta S.C., Gripp K.W., Wenger T.L., Ganesh J., Kalish J.M., Epstein M.R., Smith R., Czosek R.J., Ware S.M., Goldenberg P., Myers A., Chatfield K.C., Gillespie M.J., Zackai E.H., Lin A.E., “Nonreentrant atrial tachycardia occurs independently of hypertrophic cardiomyopathy in RASopathy patients” (opens in new tab), American Journal of Medical Genetics Part A, vol. 176, pp. 1711-1722, 2018.
- Masuho I., Fang M., Geng C., Zhang J., Jiang H., Ozgul R.K., Yilmaz D.Y., Yalnizoglu D., Yuksel D., Yarrow A., Myers A., Burn S.C., Crotwell P.L., Padilla-Lopez S., Dursun A., Martemyanov K.A., Kruer M.C., “Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia” (opens in new tab), Neurology Genetics, vol. 2, 2016.
- Myers A, du Souich C, Yang CL, Borovik L, Mwenifumbo J, Rupps R, Study C, Lehman A, Boerkoel CF, “FOXP1 haploinsufficiency: Phenotypes beyond behavior and intellectual disability?” (opens in new tab), American Journal of Medical Genetics Part A, vol. 173A, pp. 3172-3181, 2017.
- Cain JT, Kim DI, Quast M, Shivega WG, Patrick RJ, Moser C, Reuter S, Perez M, Myers A, Weimer JM, Roux KJ, Landsverk M, “Nonsense pathogenic variants in exon 1 of PHOX2B lead to translational reinitiation in congenital central hypoventilation syndrome” (opens in new tab), American Journal of Medical Genetics Part A, vol. 173A, pp. 1200-1207, 2017.
- Brennan M, Adam MP, Seaver LH, Myers A, Schelley S, Zadeh N, Hudgins L, Bernstein JA, “Increased body mass in infancy and early toddlerhood in Angelman syndrome patients with uniparental disomy and imprinting center defects” (opens in new tab), American Journal of Medical Genetics Part A, vol. 167A, pp. 142-146, 2015.
This profile was created with the help of AI.
Last updated on 5/19/2026.