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Peter H. Nguyen

Peter H. Nguyen

•Chief Health Informatics Officer, Tibor Rubin VA Medical Center
•HS Assistant Clinical Professor WOS, University of California – Irvine School of Medicine

Biography

Peter H. Nguyen, M.D., is Chief Health Informatics Officer at the Tibor Rubin VA Medical Center and HS Assistant Clinical Professor WOS at the University of California – Irvine School of Medicine. Board-certified in both internal medicine and clinical informatics, Nguyen serves as VA Site Director for the UC Irvine Clinical Informatics Fellowship and as VISN22 Artificial Intelligence Innovation Coalition Clinical Lead. He received his Doctor of Medicine from Creighton University School of Medicine, completed his internal medicine residency at the University of Arizona College of Medicine – Phoenix, and completed a fellowship in clinical informatics along with a graduate certificate in biomedical informatics from Oregon Health & Science University.

Nguyen has led numerous health informatics and artificial intelligence initiatives at the Tibor Rubin VA Medical Center, including serving as VA National Artificial Intelligence Institute Facility Lead and co-chairing the Artificial Intelligence Oversight Committee. His work spans electronic health record optimization, predictive modeling for patient risk stratification, and implementation of clinical decision support tools. He has directed projects involving discharge prediction tools, no-show appointment modeling, cardiac arrest risk triage systems, and COVID-19 severity prediction models. During the COVID-19 pandemic, he served as Informatics Lead for the Hospital Incident Command Team and helped establish the Long COVID Clinic.

Nguyen's research has focused on using social determinants of health data to identify patients at high risk for acute care utilization and poor chronic disease outcomes. His early research career included work in molecular cardiology at Tufts Medical Center, where he contributed to studies on bone morphogenetic protein signaling pathways and microRNA regulation in vascular biology. He has published in journals including the Journal of Biological Chemistry, Molecular and Cell Biology, and the American Journal of Physiology, and has presented his informatics work at national conferences including the American Medical Informatics Association meetings.

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Education

  • B.A. in Biochemistry and Molecular Biology, Boston University, 2005
  • M.S. in Biomedical Sciences, Tufts University, 2009
  • M.D., Creighton University School of Medicine, 2014
  • Graduate Certificate in Biomedical Informatics, Oregon Health & Science University, 2019
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Distinctions

  • Reviewer's Award, American Medical Informatics Association Informatics Summit, 2024
  • Ambulatory Resident of the Year, University of Arizona College of Medicine – Phoenix Internal Medicine Residency, 2017
  • Best Diagnostic Skills, University of Arizona College of Medicine – Phoenix Internal Medicine Residency, 2017
  • Cardinal Medeiros Scholar, Boston University, 2001
  • Employee of the Quarter (Q3, FY2021), Tibor Rubin VA Medical Center, 2021
  • 1st Place Award for Oral Presentation by a Fellow, Annual Academic Excellence Day, University of Arizona College of Medicine – Phoenix, 2018
  • High-Value Idea Competition Honorable Mention, Banner University Medical Center – Phoenix, 2017
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Areas of Expertise

  • Clinical Informatics
  • Social Determinants of Health
  • Electronic Health Record Optimization
  • Predictive Modeling for Healthcare
  • Artificial Intelligence in Medicine
  • Telehealth Post-Discharge Interventions
  • Pharmacogenomics Implementation

Recent Publications

  • Hamre MC, Nguyen PH, Shepard SE, Caplan JP, “Factitious mastectomy and hysterectomy: the importance of staying abreast of the medical record”, Psychosomatics, 2013.
  • Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A, “Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins”, Journal of Biological Chemistry, 2012.
  • Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G, “Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A”, Journal of Biological Chemistry, 2012.
  • Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A, “The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway”, Molecular Cell Biology, 2011.
  • Davis BN, Hilyard AS, Nguyen PH, Lagna G, Hata A, “Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha”, Molecular Cell, 2010.
  • Davis BN, Hilyard AC, Nguyen PH, Lagna GL, Hata A, “Induction of MicroRNA-221 by Platelet-Derived Growth Factor Signaling is Critical for Modulation of Vascular Smooth Muscle Phenotype”, Journal of Biological Chemistry, 2008.
  • Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A, “A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor”, Molecular and Cell Biology, 2007.
  • Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A, “Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors”, Journal of Biological Chemistry, 2007.
  • Lagna G, Nguyen PH, Ni W, Hata A, “BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells”, American Journal of Physiology: Lung Cellular and Molecular Physiology, 2006.
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Contact Information

Email: phnguye2@uci.edu

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This profile was created with the help of AI.

Last updated on 3/31/2026.