Pim J.A. Oomen
Assistant Professor, Department of Biomedical Engineering at the Henry Samueli School of Engineering
Biography
Pim J.A. Oomen, Ph.D., is Assistant Professor in the Department of Biomedical Engineering at the University of California, Irvine, with affiliations in the UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center and the Center for Complex Biological Systems. Oomen develops multiscale computational and experimental tools to advance cardiac biomechanics and electrophysiology, with a focus on improving equitable cardiovascular therapies and understanding sex differences in cardiac remodeling. Oomen received a Ph.D. from Eindhoven University of Technology in 2018 and completed postdoctoral training at the University of Virginia, where he also served as a Senior Scientist in Cardiovascular Medicine before joining UCI in 2022.
Oomen's research spans computational modeling of cardiac resynchronization therapy outcomes, sex hormone-driven cardiac remodeling, and the development of patient-specific digital twins for cardiovascular disease. His work integrates biophysics modeling with machine learning approaches to predict cardiac growth and remodeling, and he has contributed to understanding how sex-based differences affect responses to cardiac therapies. Oomen has been recognized as a Rising Star in Engineering in Health by Columbia University and Johns Hopkins University in 2021, and received the European Society of Biomechanics Student Award in 2017.
Oomen has secured funding as principal investigator from the American Heart Association Career Development Award and The Society of the Hellman Fellowship to study sex hormone-driven cardiac remodeling, and serves as co-investigator on an NHLBI R01 grant focused on cardiac resynchronization therapy. He teaches courses in biomechanics, finite-element simulation, and introductory biomedical engineering at UCI, and has mentored numerous graduate and undergraduate students. Oomen co-founded the Engineering–Pacific Symphony Orchestra New Instrument Competition and serves on multiple professional committees, including the ASME Bioengineering Division Solids Technical Committee and as co-chair of the Cardiac Physiome Workshop 2023.
Return to topEducation
- Ph.D., Eindhoven University of Technology (TU Eindhoven), 2018
- M.Sc., Eindhoven University of Technology (TU Eindhoven), 2014
- B.Sc., Eindhoven University of Technology (TU Eindhoven), 2012
Distinctions
- Rising Star in Engineering in Health, 2021
- American Heart Association Career Development Award, 2025-2028
- The Society of the Hellman Fellowship, 2025-2026
- European Society of Biomechanics Student Award for best abstract and presentation, 2017
Areas of Expertise
- Cardiac Biomechanics and Electrophysiology
- Heart Valve Tissue Engineering
- Computational Growth and Remodeling
- Multiscale Cardiovascular Modeling
- Sex Hormone-Driven Cardiac Hypertrophy
- Cardiac Resynchronization Therapy Prediction
- Atrial Fibrillation Hemodynamics
Recent Publications
- Jones CE, Oomen PJA, “Synergistic biophysics and machine learning modeling to rapidly predict cardiac growth probability” (opens in new tab), Computers in Biology and Medicine, vol. 184, pp. 109323, 2025.
- Lakshmikanthan A., Kay M., Oomen P.J.A., “Modeling the interplay of sex hormones in cardiac hypertrophic signaling” (opens in new tab), Plos Computational Biology, pp. 1-20, 2025.
- Plappert F., Oomen P.J.A., Jones C.E., Charitakis E., Karlsson L.O., Platonov P.G., Wallman M., Sandberg F., “Computational model of haemodynamics during atrial fibrillation” (opens in new tab), Journal of Physiology, 2025.
- Colebank MJ, Oomen PJO, Witzenburg CM, Grosberg A, Beard DA, Husmeier D, Olufsen MS, Chesler NC, “Guidelines for Mechanistic Modeling and Analysis in Cardiovascular Research” (opens in new tab), American Journal of Physiology Heart and Circulatory Physiology, vol. 327, pp. H473–H503, 2024.
- Bivona D.J., Ghadimi S., Wang Y., Oomen P.J.A., Malhotra R., Darby A., Mangrum J.M., Mason P.K., Mazimba S., Patel A.R., Epstein F.H., Bilchick K.C., “Machine learning of ECG waveforms and cardiac magnetic resonance for response and survival after cardiac resynchronization therapy” (opens in new tab), Computers in Biology and Medicine, vol. 178, 2024.
- Morales FL, Bivona DJ, Abdi M, Malhotra R, Monfredi O, Darby A, Mason PK, Mangrum JM, Mazimba S, Stadler RW, Epstein FH, Bilchick KC, Oomen PJA, “Noninvasive Electrical Mapping Compared with the Paced QRS Complex for Optimizing CRT Programmed Settings and Predicting Multidimensional Response” (opens in new tab), Journal of Cardiovascular Translational Research, vol. 16, pp. 1448-1460, 2023.
- Bivona DJ, Oomen PJA, Wang Y, Morales FL, Abdi M, Gao X, Malhotra R, Darby A, Mehta N, Monfredi OJ, Mangrum JM, Mason PK, Levy WC, Mazimba S, Patel AR, Epstein FH, Bilchick KC, “Cardiac Magnetic Resonance, Electromechanical Activation, Kidney Function, and Natriuretic Peptides in Cardiac Resynchronization Therapy Upgrades” (opens in new tab), Journal of Cardiovascular Development and Disease, vol. 10, pp. 409, 2023.
- Bilchick KC, Morgounova EM, Oomen PJA, Malhotra R, Mason PK, Mangrum M, Kim D, Gao X, Darby AE, Monfredi OJ, Aso JA, Franzen PM, Stadler RW, “First-In-Human Noninvasive Left Ventricular Ultrasound Pacing: A Potential Screening Tool for Cardiac Resynchronization Therapy” (opens in new tab), Heart Rhythm O2, vol. 4, pp. 79-87, 2023.
- Bivona DJ, Tallavajhala S, Abdi M, Oomen PJA, Gao X, Malhotra R, Darby AE, Monfredi OJ, Mangrum JM, Mason PK, Mazimba S, Salerno M, Kramer CM, Epstein FH, Holmes JW, Bilchick KC, “Cardiac magnetic resonance defines mechanisms of sex-based differences in outcomes following cardiac resynchronization therapy” (opens in new tab), Frontiers in Cardiovascular Medicine, vol. 9, 2022.
- Bivona DJ, Tallavajhala S, Abdi M, Oomen PJA, Gao X, Malhotra R, Darby AE, Monfredi OJ, Mangrum JM, Mason PK, Mazimba S, Salerno M, Kramer CM, Epstein FH, Holmes JW, Bilchick KC, “Machine learning for multidimensional response and survival after cardiac resynchronization therapy using features from cardiac magnetic resonance” (opens in new tab), Hearth Rhythm O2, vol. 3, no. 5, pp. 542–552, 2022.
- Oomen PJA, Phung TKN, Bilchick KC, Holmes JW, “A rapid electro-mechanical model to predict reverse remodeling following cardiac resynchronisation therapy” (opens in new tab), Biomechanics and Modeling in Mechanobiology, vol. 21, pp. 231–247, 2022.
- Hermans L.H.L., Van Kelle M.A.J., Oomen P.J.A., Lopata R.G.P., Loerakker S., Bouten C.V.C., “Scaffold Geometry-Imposed Anisotropic Mechanical Loading Guides the Evolution of the Mechanical State of Engineered Cardiovascular Tissues in vitro” (opens in new tab), Frontiers in Bioengineering and Biotechnology, vol. 10, 2022.
- Gao X, Abdi M, Auger DA, Sun C, Hanson C, Robinson A, Schumann C, Oomen PJA, Ratcliffe S, Malhotra R, Darby A, Monfredi OJ, Mangrum JM, Mason P, Mazimba S, Holmes JW, Kramer CM, Epstein FH, Salerno M, Bilchick KC, “Cardiac Magnetic Resonance Assessment of Response to Cardiac Resynchronization Therapy and Programming Strategies” (opens in new tab), JACC: Cardiovascular Imaging, vol. 14, pp. 2369-2383, 2021.
- Oomen PJA, Holland MA, Bouten CVC, Kuhl E, Loerakker S, “Mechanical models suggest that growth and remodeling play opposing roles during the development of human heart valves” (opens in new tab), Scientific Reports, vol. 8, no. 1235, 2018.
- Van Kelle MAJ, Oomen PJA, Janssen-van den Broek MWJT, Lopata RGP, Loerakker S, Bouten CVC, “Initial scaffold thickness affects the emergence of a geometrical and mechanical equilibrium in engineered cardiovascular tissues” (opens in new tab), Journal of the Royal Society Interface, vol. 115, no. 148, 2018.
- Oomen PJA, van Kelle MAJ, Oomens CWJ, Bouten CVC, Loerakker S, “Nondestructive mechanical characterization of developing biological tissues using inflation testing” (opens in new tab), Journal of the Mechanical Behavior of Biomedical Materials, vol. 74, pp. 438-447, 2017.
- Van Kelle MAJ, Oomen PJA, Bulsink JA, Janssen-van den Broek MWJT, Lopata RGP, Rutten MCM, Loerakker S, Bouten CVC, “A bioreactor to identify the driving Mechanical stimuli of tissue growth and remodeling” (opens in new tab), Tissue Engineering Part C Methods, vol. 23, no. 6, pp. 377-87, 2017.
- Oomen PJA, Loerakker S, van Geemen D, Neggers J, Goumans MJTH, van den Bogaerdt AJ, Bogers AJJC, Bouten CVC, Baaijens FPT, “Age-dependent changes of stress and strain in the human heart valve and their relation with collagen remodeling” (opens in new tab), Acta Biomaterialia, vol. 29, pp. 161-169, 2016.
- Van Geemen D, Soares ALF, Oomen PJA, Driessen-Mol A, Janssen-van den Broek MWJT, van den Bogaerdt AJ, Bogers AJJC, Goumans MJTH, Baaijens FPT, Bouten CVC, “Age-dependent changes in geometry, tissue composition and mechanical properties of fetal to adult cryopreserved human heart valves” (opens in new tab), PLoS One, vol. 11, no. 2, 2016.
- den Hamer A, Heusinkveld MHG, Traa WA, Oomen PJA, Oliva F, Del Buono A, Mafulli N, “Current techniques for management of transverse displaced olecranon fractures” (opens in new tab), Muscles, Ligaments and Tendons Journal, vol. 5, no. 2, pp. 129–140, 2015.
Most Cited Publications
- Heusinkveld MHG, den Hamer A, Traa WA, Oomen PJA, Maffulli N, “Treatment of transverse patellar fractures: A comparison between metallic and non-metallic implants” (opens in new tab), British Medical Bulletin, vol. 107, pp. 69–85, 2013.
- Lee CH, Oomen PJA, Rabbah JP, Yoganathan A, Gorman RC, Gorman III JH, Amini R, Sacks MS, “A high-fidelity and micro-anatomically accurate 3D finite element model for simulations of functional mitral valve” (opens in new tab), Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics, vol. 7945, pp. 16-24, 2013.
- Traa WA, Oomen PJA, den Hamer A, Heusinkveld MH, Maffulli N, “Biomechanical studies on transverse olecranon and patellar fractures: a systematic review with the development of a new scoring method” (opens in new tab), British Medical Bulletin, vol. 108, pp. 131-157, 2013.
Contact Information
Website: https://www.pimoomen.org
Email: poomen@uci.edu
Phone: (949) 824-9196
Address: 6084 Samueli Interdisciplinary Science and Engineering, Irvine, CA 92697-2715
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Last updated on 4/1/2026.