Siyoung Ha
Biography
Siyoung Ha, Ph.D., is an Associate Project Scientist in the Department of Ophthalmology at the University of California, Irvine. Ha received a Ph.D. in Biochemistry from Chung-Ang University in Seoul, South Korea. Ha's research focuses on genome editing and delivery systems, with prior work spanning the development of biomarkers and drug targets in prostate cancer, biosensor technologies, and drug delivery systems.
Ha has authored or co-authored over 30 peer-reviewed publications in journals including Proceedings of the National Academy of Sciences, ACS Nano, and Advanced Materials. Ha's research has addressed diverse topics including the development of siderophore-functionalized nanodrugs for antibiotic-resistant bacteria, biosensor technologies for disease detection, and molecular mechanisms of drug resistance in cancer. Ha has contributed to the identification of aberrant PI3Kδ splice isoforms as biomarkers and therapeutic targets in endocrine and prostate cancers, with particular focus on treatment resistance mechanisms.
Ha has filed two patent applications related to cancer biomarkers and biosensor technologies. Ha has presented research at multiple conferences including the American Association for Cancer Research and the American Society of Health-System Pharmacists. Prior to joining UC Irvine, Ha held research positions at the University of Maryland Eastern Shore, the Korea Research Institute of Bioscience and Biotechnology, and completed postdoctoral training at the University of Massachusetts Amherst.
Return to topEducation
- Ph.D. in Biochemistry, Chung-Ang University, 2017
- M.S. in Biochemistry, Chung-Ang University, 2014
- B.S. in Chemistry, An-dong University, 2011
Distinctions
- Research scholarship, Chung-Ang University, 2014-2017
- Excellent student scholarship, Chung-Ang University, 2014-2017
Areas of Expertise
- Molecular Biology and Biotechnology
- Prostate Cancer Biomarkers
- Drug Delivery Systems
- Importin Beta Inhibition
- Genome Editing Techniques
- Biosensor Development
- Nanomedicine Applications
Recent Publications
- Du, S. W., Palczewska, G., Dong, Z., Lauterborn, J. C., Ha, S., Palczewski, K., “TIGER: A tdTomato in vivo genome-edSeptemberrter mouse for investigating precision-editor delivery approaches.” (opens in new tab), Proceedings of the National Academy of Sciences of the United States of America, vol. 122, no. 35, pp. e2506257122, 2025.
- Wang, B. D., Lucero, A., Ha, S., Yarmohammadi, R., “PI3Kδ as a Novel Therapeutic Target for Aggressive Prostate Cancer.”, Cancers, vol. 17, no. 10, pp. 1610, 2025.
- Ha, S., Kim, J., Seo, H. W., Kim, L., Yi, Y. S., Kwon, O. S., “Siderophore-Functionalized Nanodrug for Treating Antibiotic-Resistant Bacteria.”, ACS nano, vol. 19, no. 5, pp. 5131-5145, 2025.
- Kim, K. H., Ha, S., Kwon, O. S., “TRPA1 nanovesicle-conjugated receptonics for rapid biocide screening.”, Journal of Hazardous Materials, vol. 447, pp. 135282, 2024.
- Kim, G. J., Park, S. J., Kim, L., Kim, K. H., Kim, S., An, J. E., Ha, S., Kwon, O. S., “Second Skin as Self-Protection Against γ-Hydroxybutyrate.”, ACS nano, vol. 17, no. 24, pp. 25405-25418, 2024.
- Seo, S. E., Kim, K. H., Ha, S., Kwon, O. S., “Synchronous diagnosis of respiratory syncytial virus variants via receptonics based on modeling receptor-ligand dynamics.”, Advanced Materials, vol. 36, no. 9, pp. 2303079, 2024.
- Ha, S., Gujrati, H., Wang, B. D., “Aberrant PI3Kδ Splice Isoform as a Potential Biomarker and Novel Therapeutic Target for Endocrine Cancers.”, Frontiers, vol. 14, pp. 1190479, 2023.
- Gujrati, H., Ha, S., Wang, B. D., “Deregulated microRNAs Involved in Prostate Cancer Aggressiveness and Treatment Resistance Mechanisms.”, Cancers, vol. 15, no. 12, pp. 3140, 2023.
- Seo, S. E., Ha, S., Kwon, O. S., “Reusable electronic tongue based on TRPV1 nanodisc-conjugated graphene field-effect transistor for a spiciness-related pain evaluation.”, Advanced Materials, vol. 35, no. 19, pp. 2206198, 2023.
- Ha, S., Wang, B. D., “Molecular Insight into Drug Resistance Mechanism Conferred by Aberrant PIK3CD Splice Variant in African American Prostate Cancer.”, Cancers, vol. 15, no. 4, pp. 1337, 2023.
- Kim, K. H., Moon, D., An, J. E., Park, S. J., Seo, S. E., Ha, S., Kwon, O. S., “Wireless portable bioelectronic nose device for multiplex monitoring toward food freshness/spoilage.”, Biosensors and Bioelectronics, vol. 215, pp. 114551, 2022.
- Gujrati, H., Ha, S., Wang, B. D., “Downregulation of miR-99b-5p and Upregulation of Nuclear mTOR Cooperatively Promotes the Tumor Aggressiveness and Drug Resistance in African American Prostate Cancer.”, IJMS, vol. 23, no. 17, pp. 9643, 2022.
- Ha, S., Kim, J., Park, C. S., Kwon, O. S., “In situ, real-time, colorimetric detection of γ-hydroxybutyric acid (GHB) using self-protection products coated with chemical receptor-embedded hydrogel.”, Biosensors and Bioelectronics, vol. 207, pp. 114195, 2022.
- Kim, J. J., Ha, S., Kim, L., Kato, Y., Wang, Y., Okutani, C., Someya, T., “Antimicrobial second skin using copper nanomesh.”, Proceedings of the National Academy of Sciences, vol. 119, no. 24, pp. e2200830119, 2022.
- Kim, K. H., Park, C. S., Park, S. J., Kim, J., Seo, S. E., An, J. E., Ha, S., Kwon, O. S., “In-situ food spoilage monitoring using a wireless chemical receptor-conjugated graphene electronic nose”, Biosensors and Bioelectronics, vol. 200, pp. 113908, 2022.
- Gujrati, H., Ha, S., Mohamed, A., Wang, B. D., “MicroRNA-mRNA Regulatory Network Mediates Activation of mTOR and VEGF Signaling in African American Prostate Cancer”, International journal of molecular sciences, vol. 23, no. 6, pp. 2926, 2022.
- An, J. E., Kim, K. H., Park, S. J., Seo, S. E., Kim, J., Ha, S., Kwon, O. S., “Wearable cortisol aptasensor for simple and rapid real-time monitoring”, ACS sensors, vol. 7, no. 1, pp. 99-108, 2022.
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Last updated on 5/22/2026.