Veedamali S. Subramanian
Biography
Veedamali S. Subramanian, Ph.D., is Associate Professor in Research-HCOMP at the University of California, Irvine. Subramanian received a Ph.D. in Immunogenetics from the University of Madras, India, and was awarded a gold medal for best Ph.D. thesis work by the university in 1996. His research focuses on the molecular and cellular mechanisms of vitamin transport in intestinal, lung, and neuronal cells, with particular emphasis on vitamins C, B1 (thiamine), and B2 (riboflavin).
Subramanian has served as principal investigator on multiple NIH grants, including an R01 examining the physiology and pathophysiology of intestinal vitamin C uptake and current R03 grants investigating vitamin C transport in Alzheimer's disease and nicotine-induced lung ailments. He also recently awarded VA Merit Review grant on vitamin C's role in modulating immune responses and intestinal inflammation. His work has elucidated how chronic alcohol exposure, inflammatory conditions, and bacterial infections affect vitamin transport processes, and has identified clinical mutations in vitamin transporter genes associated with neurological and systemic disorders.
Subramanian serves on the Institutional Animal Care Use Committees at both the Veterans Affairs Medical Center in Long Beach and UC Irvine. Additionally, he also serves as a space committee member at UCI. He has been a member of the American Gastroenterological Association's abstract review committee since 2014 and served as councilor for the Obesity, Metabolism & Nutrition section from 2013 to 2023. He is also a member of the American Physiological Society's award committee for the Gastrointestinal and Liver Physiology section. Subramanian has authored over 100 peer-reviewed publications and serves as a reviewer for numerous journals in physiology, cell biology, and nutrition.
Return to topEducation
- B.S. in Zoology, Madurai Kamaraj University, India, 1985
- M.S. in Zoology, Madurai Kamaraj University, India, 1987
- M.Phil. in Zoology, University of Madras, India, 1989
- Ph.D in Immunogenetics (Zoology), University of Madras, India, 1995
Areas of Expertise
- Intestinal Nutrient Transport Physiology
- Vitamin C Transporter Regulation
- Thiamine Uptake Mechanisms
- Riboflavin Cellular Homeostasis
- Neuronal Vitamin Transporter Expression
- Chronic Alcohol Effects
- Inflammatory Cytokine Signaling Pathways
Recent Publications
- Kang, N., Subramanian, V. S., Agrawal, A., “Influence of Aging and Immune Alterations on Susceptibility to Pneumococcal Pneumonia in the Elderly” (opens in new tab), Pathogens, vol. 14, pp. 41, 2025.
- Teafatiller, T., Subramanya, S. B., Lambrecht, N., Subramanian, V. S., “Salmonella Typhimurium infection reduces the ascorbic acid uptake in the intestine” (opens in new tab), Mediators of Inflammation, vol. 2023, pp. 2629262, 2023.
- Rashid, M. A., Lin-Moshier, Y., Gunaratne, G. S., Subramanian, S., Marchant, J. S., Subramanian, V. S., “Vitamin C transport in neurons and epithelia is regulated by Secretory Carrier-Associated Membrane Protein-2 (SCAMP2)” (opens in new tab), International Journal of Biological Macromolecules, vol. 230, pp. 123205, 2023.
- Teafatiller, T., Oasis, P., Kitazawa, M., Agrawal, A., Subramanian, V. S., “Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal cells” (opens in new tab), Journal of Nutritional Biochemistry, vol. 120, pp. 109413, 2023.
- Teafatiller, T., Kitazawa, M., Agrawal, A., Subramanian V. S., “Regulation of human sodium-dependent vitamin C transporter-2 function in neuronal cells by ubiquitin E3 ligase Nedd4-1”, Physiology, vol. 38, no. S1, pp. 5696213, 2023.
- Rashid, M. A., Lin-Moshier, Y., Marchant, J. S., Subramanian, V. S., “Secretory carrier-associated membrane protein-2 upregulates ascorbic acid uptake via the human sodium-dependent vitamin C transporter-1”, Gastroenterology, vol. 162, pp. S-204, 2022.
- Rashid, M. A., Marchant, J. S., Subramanian, V.S., “Inhibition of Vitamin C transport impairs neuronal differentiation of hiPSCs”, FASEB J, vol. 36, no. S1, pp. L7429, 2022.
- Heskett, C. W., Teafatiller, T., Hennessey, C., Gareau, M. G., Marchant J. S., Said, H. M., Subramanian, V. S., “Enteropathogenic Escherichia coli infection inhibits intestinal ascorbic acid uptake via dysregulation of its transporter expression” (opens in new tab), Digestive Diseases and Sciences, vol. 66, pp. 2250-2260, 2021.
- Teafatiller, T., Heskett, C. W., Agrawal, A., Marchant, J.S., Baulch, J. E., Munjal M. Acharya, M.M., Subramanian, V. S., “Upregulation of Vitamin C Transporter Functional Expression in 5xFAD Mouse Intestine” (opens in new tab), Nutrients, vol. 13, pp. 617, 2021.
- Subramanian, V. S., Teafatiller, T., Moradi, H., Marchant, J. S., “Histone deacetylase inhibitors regulate vitamin C transporter functional expression in intestinal epithelial cells” (opens in new tab), Journal of Nutritional Biochemistry, vol. 98, pp. 108838, 2021.
- Subramanian, V. S., Teafatiller, T., Agrawal, A., Kitazawa, M., Marchant, J. S., “Effect of lipopolysaccharide and TNFα on neuronal ascorbic acid uptake” (opens in new tab), Mediators of Inflammation, vol. 2021, pp. 1-11, 2021.
- Subramanian, V. S., Teafatiller, T., Vidal, J., Gunaratne, G. S., Rodriguez-Ortiz, C. J., Kitazawa, M., Marchant, J. S., “Calsyntenin 3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake” (opens in new tab), International Journal of Biological Macromolecules, vol. 192, pp. 1178-1184, 2021.
- Teafatiller, T., Agrawal, S., Rahmatpanah F., Subramanian, V. S., Agrawal, A., “Vitamin C enhances the antiviral response of airway epithelial cells” (opens in new tab), Biomolecules, vol. 11, pp. 1148, 2021.
Most Cited Publications
- Vaziri, N. D., Yuan, J, Rahimi, A., Ni, Z., Said, H, Subramanian, V. S., “Disintegration of colonic epithelial tight junction in uremia: A likely cause of CKD-associated inflammation” (opens in new tab), Nephrology dialysis transplantation, vol. 27, pp. 2686-2693, 2012.
- Said, H. M., Balamurugan, K., Subramanian, V. S., Marchant, J.S., “Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine” (opens in new tab), American Journal of Physiology Gastrointestinal and Liver Physiology, vol. 286, pp. G491-G498, 2004.
- Subramanya, B. S., Subramanian, V. S., Said, H. M., “Chronic alcohol consumption and intestinal thiamin absorption: Effects on physiological and molecular parameters of the uptake process” (opens in new tab), American Journal of Physiology Gastrointestinal and Liver Physiology, vol. 299, pp. G23-G31, 2010.
- Subramanian, V. S., Marchant, J. S., Said, H. M., “Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via the hTHTR2: biotin is not a substrate for hTHTR2” (opens in new tab), American Journal of Physiology Cell Physiology, vol. 291, pp. C851-C859, 2006.
- Subramanian, V. S., Marchant, J. S., Boulware, M. J., Said, H. M., “A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter in polarized epithelia” (opens in new tab), Journal of Biological Chemistry, vol. 279, pp. 27719-27728, 2004.
- Subramanian, V. S., Marchant, J. S., Parker, I., Said, H. M., “Cell biology of the human thiamine transporter-1 (hTHTR-1) Intracellular Trafficking and membrane targeting mechanisms” (opens in new tab), Journal of Biological Chemistry, vol. 278, pp. 3976-3984, 2003.
- Subramanian, V. S., Goyal, J., Miwa, M., Sugatama, J., Akiyama, M., Liu, M., Subbaiah, P.V., “Role of lecithin-Cholesterol acyltransferase in the metabolism of oxidized phospholipids in plasma. Studies with platelet activating factor-acetyl hydrolase-deficient plasma” (opens in new tab), Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, vol. 1439, pp. 95-109, 1999.
- Subramanian, V. S., Constantinescu, A. R., Benke, P. J., Said, H. M., “Mutations in SLC5A6 associated with brain, immune, bone and intestinal dysfunction in a young child” (opens in new tab), Human Genetics, vol. 136, pp. 253-261, 2017.
- Reidling, J. C., Subramanian, V. S., Dudeja, P. K., Said, H. M., “Expression and promoter analysis of SLC19A2 in the human intestine” (opens in new tab), Biochimica Et Biophysica Acta Biomembranes, vol. 1561, pp. 180-187, 2002.
- Subramanian, V. S., Subramanya B. S., Rapp L., Marchant, J. S., Ma, T.Y., Said, H. M., “Differential expression of human riboflavin transporters-1, -2 &-3 in polarized epithelia: An important role for hRFT2 in intestinal riboflavin uptake” (opens in new tab), Biochimica Et Biophysica Acta Biomembranes, vol. 1808, pp. 3016-3021, 2011.
Contact Information
Email: vsubrama@uci.edu
Phone: (949) 824-3084
Address: 839 Health Science Road Med Sci C348 Irvine, CA 92697
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Last updated on 6/25/2026.