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Luke Walls-Smith

Luke Walls-Smith

•HS Assistant Clinical Professor III, University of California, Irvine Department of Emergency Medicine
•Director of Quality Improvement, UCI Emergency Department

Biography

Luke Walls-Smith, M.D., is HS Assistant Clinical Professor and Director of Quality Improvement in the Department of Emergency Medicine at the University of California, Irvine. He completed his medical degree at the University of California, Irvine School of Medicine, followed by an emergency medicine residency at UCI Medical Center, where he served as Academic Chief Resident. He subsequently completed a fellowship in Emergency Department Administration and Operations at UCI Medical Center.

Walls-Smith's work centers on emergency department operations and quality improvement. In his administrative role, he has led a range of interdisciplinary initiatives including the development of clinical algorithms and emergent CT ordering, redesign of patient triage workflows, and implementation of remote cardiac monitoring technology. He serves on numerous hospital governance and operations committees and leads the UCI Emergency Department's Case Review Committee. He also serves as the Geriatric Emergency Department Physician Champion, overseeing site reaccreditation efforts.

Walls-Smith holds board certification from the American Board of Emergency Medicine and is a member of the Society of Academic Emergency Medicine and the American College of Emergency Physicians. His research spans emergency department operations, patient safety, and clinical care pathways. He is an active clinical teacher, supervising and instructing residents at UCI Medical Center.

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Education

  • B.S. in Biochemistry, University of California, Santa Barbara, 2014
  • M.D., University of California, Irvine, School of Medicine, 2020
  • Emergency Medicine Residency, University of California, Irvine Medical Center, 2023
  • Fellowship in Emergency Department Administration & Operations, University of California, Irvine Medical Center, 2024
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Distinctions

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    Areas of Expertise

    • Emergency Department Administration and Operations
    • Sepsis Protocol Compliance
    • Geriatric Patient Care Optimization

    Recent Publications

    • Weiland, A., Yim, J., Quan, K., Bittencourt, C., Madey, K., Gasset, A., Briars, E., Sater, M., Billings, N., Shimabukuro, J., Uy, N., Walls-Smith, L., Tjoa, T., Huang, S., “Routine Whole-Genome Sequencing of Hospital Bacterial Isolates Identifies the ED as a Source of Transmission”, 2025. Presented at Society for Healthcare Epidemiology of America Annual Conference, Florida, April 27-30, 2025.
    • Nguyen, A., Walls-Smith, L., Nahmias, J., Spiegelman, L., “Analyzing the Impact of Various Clinical Care Pathways on Trauma Recidivism Rates: A Retrospective Cohort Analysis”, 2024. Presented at 10th World Academic Congress of Emergency Medicine Conference, Rome, Italy, November 6-9, 2024.
    • Wray, Alisa, Walls-Smith, Luke, “Other Components of the Practice of Emergency Medicine”, Carol Rivers Emergency Medicine: Preparing for the Written Board Exam and Review of Core Content, 2022.
    • Simon, Anna J., Walls-Smith, Luke, Plaxco, Kevin W., “Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel”, Analyst, vol. 143, no. 11, pp. 2531-2538, 2018.
    • Walls-Smith, Luke, Peña, Jonathan, “Perianal Abscess”, Journal of Education and Teaching in Emergency Medicine, vol. 3, no. 1, 2018.
    • Simon, Anna J., Walls-Smith, Luke, “Simultaneous Measurement of the Dissolution Kinetics of Responsive DNA Hydrogels at Multiple Length Scales”, ACS Nano, vol. 11, no. 1, pp. 461-468, 2017.
    • Walls-Smith, L., Simon, A., Plaxco, K., “Optimization of the Thermodynamics and Kinetics of Biopolymer-Based Smart Materials”, 2014. Presented at SACNAS Conference, San Antonio, Texas.
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    Contact Information

    Email: wallssml@uci.edu

    Phone: (714) 456-5239

    Address: 3800 W. Chapman Ave., Suite 3200, Orange, CA 92868

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    This profile was created with the help of AI.

    Last updated on 10/5/2026.