Jun Xie

Associate Specialist, Department of Urology, UCI

Biography

Jun Xie is an Associate Specialist in the Department of Urology at the University of California, Irvine. Xie has worked at UCI since 2004, progressing through positions in the Departments of Orthopedic Surgery, Ophthalmology, Epidemiology, and Urology. Prior to joining UCI, Xie worked as a librarian in China and as an accounting clerk in Montreal, Canada.

Xie holds a Bachelor of Arts in Library Science from Zhongshan University in Guangzhou, China, and completed vocational studies in accounting and automated accounting and finance at Shadd Business Center in Montreal, Quebec, Canada. Xie's technical expertise spans molecular biology techniques, cell culture, immunohistochemistry, animal management, and quality control for stem cell-based clinical trials.

Xie has contributed to 19 peer-reviewed publications and 16 conference abstracts, primarily focused on cancer research including studies of Wnt signaling pathways, natural compounds in cancer prevention and treatment, and therapeutic approaches for prostate, bladder, and bone cancers. The research has examined mechanisms of tumor growth, metastasis, and drug resistance across multiple cancer types, with recent work exploring copper metabolism and metabolic pathways in cancer therapy.

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Education

Bachelor of Arts in Library Science, Zhongshang University, 1985
Diploma of Vocational Studies in Accounting, Shadd Business Center, 2002
Attestation of Vocational Specialization in Automated Accounting & Finance, Shadd Business Center, 2002

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Areas of Expertise

Cancer Biology and Therapeutics
Wnt Signaling Pathway Inhibition
Osteosarcoma Tumor Suppression
Prostate Cancer Chemoprevention
Kavalactone Anticancer Mechanisms
Copper Transporter Targeting
Urothelial Carcinoma Prevention

Recent Publications

Song L, Nguyen V, Xie J, Jia S, Chang CJ, Uchio E, Zi X, “ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer” (opens in new tab), Molecular Cancer Therapeutics, vol. 23, pp. 854-863, 2024.
Liankun Song, Noriko Yokoyama, Jun Xie, Yunjie Hu, Zhenyu Jia, Beverly Wang, Dan Mercola, Edward Uchio, Thomas Ahlering, Michael Lilly, Xiaolin Zi, “Overexpression of phosphoserine phosphatase (PSPH) in prostate cancer and in tumor microenvironment promotes tumor cell proliferation”, Cancer Research, vol. 84, no. 6_Supplement, pp. 773-773, 2024.
Xu X, Tian X, Song L, Xie J, Liao JC, Meeks JJ, Wu XR, Gin GE, Wang B, Uchio E, Zi X, “Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation” (opens in new tab), Biomolecules, vol. 13, pp. 521, 2023.
Liu Z, Yokoyama NN, Song L, Xie J, Sadeghi Z, Wu YX, Yee S, Wu XR, Wang B, Uchio E, Zi X, “Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism” (opens in new tab), Molecules, vol. 28, pp. 1666, 2023.
Liu Z, Yokoyama NN, Song L, Xie J, Sadeghi Z, Wu YX, Yee S, Wu XR, Wang B, Uchio E, Zi X, “The Potent Anti-Tumor Effects of Rhodiola Drinking Are Associated with the Inhibition of the mTOR Pathway and Modification of Tumor Metabolism in the UPII-Mutant Ha-Ras Model” (opens in new tab), Cancers, vol. 15, pp. 3086, 2023.
Liankun Song, Vyvyan Nguyen, Jun Xie, Matthew Tippin, Le TP Truong, Christopher A Blair, Beverly Wang, Edward Uchio, Xiaolin Zi, “ATPase copper transporting beta (ATP7B) contributes to acquired docetaxel resistance in human prostate cancer”, Cancer Research, vol. 83, no. 7_Supplement, pp. 1687-1687, 2023.
Liu Z, Song L, Xie J, Simoneau AR, Uchio E, Zi X, “Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice” (opens in new tab), Pharmaceutics, vol. 14, pp. 496, 2022.
Li X, Song L, Xu S, Tippin M, Meng S, Xie J, Uchio E, Zi X, “Kava root extracts hinder prostate cancer development and tumorigenesis by involvement of dual inhibition of MAO-A and LSD” (opens in new tab), Journal of Translational Genetics and Genomics, vol. 5, pp. 163, 2021.
Schomberg J., Wang Z., Farhat A., Guo K.L., Xie J., Zhou Z., Liu J., Kovacs B., Liu-Smith F., “Luteolin inhibits melanoma growth in vitro and in vivo via regulating ECM and oncogenic pathways but not ROS” (opens in new tab), Biochemical Pharmacology, vol. 177, 2020.
Jandial DD, Krill LS, Chen L, Wu C, Ke Y, Xie J, Hoang BH, Zi X, “Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin” (opens in new tab), Molecules, vol. 22, pp. E462, 2017.
Cooper AE, Cho JH, Menges S, Masood S, Xie J, Yang J, Klassen H, “Immunosuppressive Treatment Can Alter Visual Performance in the Royal College of Surgeons Rat” (opens in new tab), Journal of Ocular Pharmacology and Therapeutics, vol. 32, pp. 296-303, 2016.
Li X, Liu Z, Xu X, Blair CA, Sun Z, Xie J, Lilly MB, Zi X, “Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice” (opens in new tab), PLoS One, vol. 7, no. 2, pp. e31213, 2012.
Yi Guo, Alexander Christ, Ariel Czerwinski, Rui Ni, Jun Xie, Xiaolin Zi, Bang H Hoang, “Frzb/sFRP3 inhibits lung metastasis of osteosarcoma”, Proc Am Assoc Cancer Res, vol. 51, pp. 2348, 2010.
Samia Ghaffar, Yi Guo, Peter McQueen, Alex Christ, Khoa Tu, Jun Xie, Xiaolin Zi, Bang Hoang, “Wnt-Signaling regulates angiogenesis by regulating Neuropilin-1 expression in osteosarcoma”, Proc Am Assoc Cancer Res, vol. 51, pp. 3963, 2010.
Tang Y, Simoneau AR, Yi G, Xie J, Hoang BH, Zi X, “Ectopic expression of Wnt inhibitory factor-1 (WIF1) in prostate cancer PC-3 cell line decreases cellular invasiveness and tumor growth associated with both in vitro and in vivo increased expression of E-cadherin and decreased expression of Vimentin”, Am Urol Assoc Abstract, 2009.
Guo Y, Zi X, Sworder B, Xie J, Hoang BH, “Overexpression of secreted Wnt antagonists decreases invasion and tumorigenesis of soft tissue sarcomas”, Proc Am Assoc Cancer Res, vol. 48, 2007.
Tang Y, Simoneau AR, Guo Y, Liao W, Hope C, Xie J, Holcombe RF, Jurnak FA, Hoang BH, Zi X, “Recombinant WIF-1 domain protein up-regulates p27/KIP1 and p21/WAF-1 and inhibits cell proliferation of bladder cancer cells via G1 arrest”, Proc Am Assoc Cancer Res, vol. 48, 2007.

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Most Cited Publications

Zi X, Guo Y, Simoneau AR, Hope C, Xie J, Holcombe RF, Hoang BH, “Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness” (opens in new tab), Cancer Research, vol. 65, pp. 9762-70, 2005.
Yee D, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, McQueen P, Atreya D, Xie J, Simoneau AR, Hoang BH, Zi X, “The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition” (opens in new tab), Molecular Cancer, vol. 9, pp. 162, 2010.
Rubin EM, Guo Y, Tu K, Xie J, Zi X, Hoang BH, “Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma” (opens in new tab), Molecular Cancer Therapeutics, vol. 9, pp. 731-41, 2010.
Guo Y, Zi X, Koontz Z, Kim A, Xie J, Gorlick R, Holcombe RF, Hoang BH, “Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells” (opens in new tab), Journal of Orthopaedic Research, vol. 25, pp. 964-71, 2007.
Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X, “WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells” (opens in new tab), Molecular Cancer Therapeutics, vol. 8, pp. 458-68, 2009.
Tang Y, Li X, Liu Z, Simoneau AR, Xie J, Zi X, “Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth” (opens in new tab), International Journal of Cancer, vol. 127, pp. 1758-68, 2010.
Tang Y, Simoneau AR, Xie J, Shahandeh B, Zi X, “Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53” (opens in new tab), Cancer Prevention Research, vol. 1, no. 6, pp. 439-51, 2008.
Tang Y, Parmakhtiar B, Simoneau AR, Xie J, Fruehauf J, Lilly M, Zi X, “Lycopene enhances docetaxel's effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels” (opens in new tab), Neoplasia, vol. 13, pp. 108-19, 2011.
Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH, “Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling” (opens in new tab), Cancer Research, vol. 68, pp. 3350-60, 2008.
Guo Y, Rubin EM, Xie J, Zi X, Hoang BH, “Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model” (opens in new tab), Clinical Orthopaedics and Related Research, vol. 466, pp. 2039-45, 2008.

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Contact Information

Email: xiej@uci.edu

Phone: (949) 824-7694

Address: Gross Hall, Room 1200

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Last updated on 5/14/2026.