Yalda Yazdani
Biography
Yalda Yazdani, M.D., is a Postdoctoral Research Fellow at the University of California Irvine. She received her medical doctorate from the School of Medicine at Tabriz University of Medical Sciences, where her thesis focused on curcumin and targeting of molecular and metabolic pathways in multiple sclerosis. Her research spans cancer immunotherapy, nanomedicine, and viral immunopathology, with particular emphasis on drug delivery systems and immune modulation. At UC Irvine, she works on single-cell and spatial multi-omics in the classification and treatment of head and neck cancer.
Yazdani has published 39 peer-reviewed articles with over 850 citations, achieving an h-index of 15. Her publications appear in journals across multiple disciplines, including work on nanoparticle-based drug delivery systems, combination immunotherapy approaches, and biosensor development for disease detection. Her research encompasses both experimental laboratory work using in vitro and in vivo models and computational approaches involving statistical analysis of large medical databases.
Prior to her current position, Yazdani served as a postdoctoral researcher at the Immunology Research Center at Tabriz University of Medical Sciences from 2022 to 2024, where she conducted research using molecular and histological assays including qPCR, ELISA, Western blot, and immunohistochemistry. She has reviewed manuscripts for multiple journals including Laryngoscope, Otology & Neurotology, and Frontiers in Immunology. Her technical expertise includes cell culture, quantitative PCR, biomedical data analysis using R and SQL, and working with animal models.
Return to topAreas of Expertise
- Cancer Immunotherapy
- Nanoparticle Drug Delivery Systems
- Mesenchymal Stem Cell Therapy
- Immune Checkpoint Inhibitors
- Single-Cell Multi-Omics Analysis
- Biosensor Development for Diagnostics
- Head and Neck Cancer
Recent Publications
- Yazdani Y., Lee E.J., Francis A., Nedjat S., Abouzari M., Djalilian H.R., “Migraine Features in Patients With Sudden Sensorineural Hearing Loss” (opens in new tab), Otolaryngology Head and Neck Surgery United States, vol. 174, pp. 1263-1269, 2026.
- Shenoy S., Lee E.J., Nedjat S., Yazdani Y., Djalilian H.R., Abouzari M., “Ethnic, Gender, and Other Demographic Disparities in Cochleovestibular Symptoms in the United States” (opens in new tab), Otology and Neurotology, vol. 47, pp. e690-e697, 2026.
- Yazdani Y., Tawk K., Dichter A., Mazhari N., Abouzari M., Djalilian H.R., “In-Office Paper Patch Placement for Tympanic Membrane Perforation” (opens in new tab), Otology Neurotology Official Publication of the American Otological Society American Neurotology Society and European Academy of Otology and Neurotology, vol. 47, pp. 611-615, 2026.
- Yazdani Y., Alivirdiloo V., Hajiabbasi M., Mohammadi M., Hosseini S., Gargari S.O., Kheradmand R., Hatefnia F., Mobed A., “Nanoparticle-enhanced approaches to stroke: Overcoming challenges in diagnosis and treatment” (opens in new tab), Nanomedicine Nanotechnology Biology and Medicine, vol. 72, 2026.
- Yazdani Y., Lee E.J., Tawk K., Abouzari M., Djalilian H.R., “Adjunctive Serum Drops to Paper Patch for Tympanic Membrane Perforation” (opens in new tab), Annals of Otology Rhinology and Laryngology, 2026.
- “Recent advancements in nanomaterial-based biosensors for diagnosis of breast cancer: a comprehensive review” (opens in new tab), Cancer Cell International, vol. 25, no. 1, pp. 50, 2025.
- “Academic Textbook: The Role of Melatonin in Pathogenesis and Treatment of Autoimmune Diseases”, Kindle, vol. 2, no. 1, pp. 1-126, 2025.
- “A Systematic Review: State of the Science on Diagnostics of Hidden Hearing Loss” (opens in new tab), Diagnostics, vol. 15, no. 6, pp. 742, 2025.
- “A Novel Bispecific Antibody CVL006 Superior to AK112 for Dual Targeting of PD-L1 and VEGF in Cancer Therapy”, Qeios, 2025.
- Vahidi R., Yazdani Y., Djalilian H.R., “Biomodal Neurostimulation in Tinnitus Treatment” (opens in new tab), Tinnitus New Therapeutic Tools and Techniques, pp. 199-219, 2025.
- Yazdani Y., Kani N., Rastegar A.S., Djalilian H.R., “Massive Cholesteatoma With Facial Nerve, Middle and Posterior Fossa Dehiscence With Neck Extension” (opens in new tab), Ear Nose and Throat Journal, 2025.
- “The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial” (opens in new tab), Scientific Reports, vol. 14, no. 1, pp. 1053, 2024.
- “Fabrication of poly (lactic-co-glycolic acid)/mesoporous silica composite nanofibers for controllable co-delivery of 5-fluorouracil and curcumin against HT-29 colon cancer cells” (opens in new tab), Journal of Materials Science, vol. 59, no. 5, pp. 2104-2120, 2024.
- “Nanodiagnostics in global eradication of hepatitis C virus” (opens in new tab), Clinica Chimica Acta, vol. 565, pp. 120013, 2024.
- “The State-of-the-art overview to application of deep learning in accurate protein design and structure prediction” (opens in new tab), Topics in Current Chemistry, vol. 382, no. 3, pp. 23, 2024.
- “PD-L1 and PD-1 in Immune Regulation and Their Implications in Blood Cancers” (opens in new tab), Advances in Cancer Biology-Metastasis, vol. 11, pp. 100125, 2024.
- “Facial Paralysis in Otitis Media Due to Granulomatosis with Polyangiitis” (opens in new tab), Ear Nose and Throat Journal, vol. 103, no. 2_suppl, pp. 12S-15S, 2024.
- “The Top 100 Cited Articles in Otology and Neurotology and Analysis of Female Authorship” (opens in new tab), Otology and Neurotology, vol. 46, pp. 10-1097, 2024.
- “Sensitive and Cost-Effective Tools in the Detection of Ovarian Cancer Biomarkers” (opens in new tab), Analytical Science Advances, vol. 5, no. 9-10, pp. e202400029, 2024.
- “Sustained in vitro delivery of metformin-loaded mesoporous silica nanoparticles for delayed senescence and stemness preservation of adipose-derived stem cells” (opens in new tab), Journal of Drug Delivery Science and Technology, vol. 87, pp. 104769, 2023.
Most Cited Publications
- “A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system” (opens in new tab), International journal of pharmaceutics, vol. 624, pp. 121878, 2022.
- “The deep learning applications in IoT-based bio-and medical informatics: a systematic literature review” (opens in new tab), Neural Computing and Applications, vol. 36, no. 11, pp. 5757-5797, 2024.
- “An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19” (opens in new tab), Journal of Nanobiotechnology, vol. 20, no. 1, pp. 1-26, 2022.
- “The personal health applications of machine learning techniques in the internet of behaviors” (opens in new tab), Sustainability Switzerland, vol. 15, no. 16, pp. 12406, 2022.
- “Enhanced anti-cancer effect of artemisinin-and curcumin-loaded niosomal nanoparticles against human colon cancer cells” (opens in new tab), Medical Oncology, vol. 40, no. 6, pp. 170, 2023.
- “Spotlight on therapeutic efficiency of mesenchymal stem cells in viral infections with a focus on COVID-19” (opens in new tab), Stem Cell Research and Therapy, vol. 13, no. 1, pp. 257, 2022.
- “Nivolumab plus ipilimumab combination therapy in cancer: Current evidence to date” (opens in new tab), International Immunopharmacology, vol. 117, pp. 109881, 2023.
- “Combination therapy with nivolumab (anti-PD-1 monoclonal antibody): a new era in tumor immunotherapy” (opens in new tab), International Immunopharmacology, vol. 113, pp. 109365, 2022.
- “Diagnostic Performance of Ultrasonography for Identification of Small Bowel Obstruction; a Systematic Review and Meta-analysis” (opens in new tab), Archives of Academic Emergency Medicine, vol. 12, no. 1, pp. e33, 2024.
- “NFR2/ABC transporter axis in drug resistance of breast cancer cells” (opens in new tab), Molecular Biology Reports, vol. 50, no. 6, pp. 5407-5414, 2023.
Contact Information
Email: yyazdani@uci.edu
Phone: (714) 456-5753
Address: UCIMC-ENT 333 City Blvd West, Suite 525 Orange
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Last updated on 5/19/2026.