Zhibin Guan
Biography
Zhibin Guan, Ph.D., is Professor of Chemistry, Biomedical Engineering, Chemical Engineering, and Material Sciences at the University of California, Irvine. Guan received his Ph.D. in Polymer Chemistry from the University of North Carolina at Chapel Hill in 1994, where he worked under the direction of J. DeSimone. He completed postdoctoral training at Caltech with F. Arnold, who was awarded the Nobel Prize in Chemistry in 2018. Before joining UCI in 2000, Guan worked as a research chemist at DuPont Central Research in Wilmington, Delaware.
Guan's research focuses on bioinspired design of dynamic polymeric materials, development of sustainable polymeric materials, and design of functional biomaterials for gene delivery and biomedical applications. His work has contributed to the development of self-healing polymers, vitrimers with tunable properties, and electrically fueled active supramolecular materials. Guan has also developed methods for recycling polyethylene into liquid fuels through catalytic dehydrogenation and olefin metathesis, and created dendronized polymers for efficient delivery of various RNAs.
Guan is a Fellow of the American Association for Advancement of Science and recipient of the Humboldt Bessel Research Award from the Alexander von Humboldt Foundation. He has received the Camille Dreyfus Teacher-Scholar Award, the NSF CAREER Award, and the Beckman Young Investigator Award. Guan has authored over 130 peer-reviewed publications and holds 38 patents. He served as Chair of the Gordon Research Conference on Bioinspired Materials in 2018 and is a member of the Scientific Advisory Board for the National Center of Competence in Research Bio-Inspired Materials in Switzerland.
Return to topEducation
- B.S. in Chemistry, Peking University, 1987
- M.S. in Polymer Chemistry, Peking University, 1990
- Ph.D. in Polymer Chemistry, University of North Carolina, 1994
Distinctions
- Fellow of the American Association for Advancement of Science (AAAS), 2008
- Humboldt Bessel Research Award, Alexander von Humboldt Foundation, Germany, 2006-2007
- Chair of the Gordon Research Conference on Bioinspired Materials, 2018
- JSPS Invitation Fellowship for Research (long-term), Japan, 2016
- Beckman Young Investigator Award, Arnold & Mabel Beckman Foundation, 2001-2004
- Camille Dreyfus Teacher-Scholar Award, 2005-2010
- 3M Non-Tenured Faculty Award, 3M Company, 2002-2003
- DuPont Young Professor Award, DuPont Company, 2001-2004
- Research Innovation Award, University of California, 2005
- Dobbins Fellowship, University of North Carolina at Chapel Hill, 1992
Areas of Expertise
- Bioinspired Polymer Design
- Self-Healing Thermoplastic Elastomers
- Dendritic Nanoparticle Synthesis
- Olefin Polymerization Catalysis
- Electrically Fueled Active Materials
- Dynamic Covalent Crosslinking
- Dissipative Supramolecular Assembly
Recent Publications
- Zeinalvand L., Barpuzary D., Ueon T.H., Lai W.B., Song Y., Li Z., Dhaoui R., Idris N.S., Peddireddy K.R., Robertson-Anderson R.M., Tobias D.J., Guan Z., Green J.R., Patterson J.P., “Nanoscale Interfacial Organization Governs Maturation and Collapse in Passive versus Active Condensates” (opens in new tab), Journal of the American Chemical Society, vol. 148, pp. 17967-17976, 2026.
- Urbach, Z., Marrufo, N., Do, Q. T., Le, J.N., Wierzbicki, M., Song, Y., Mustafa, K., Wang, F., Egelman, E.W., Guan, Z., Tobias, D., Hochbaum, A. I., “Sequence Programmable Order–Disorder Transitions in Supramolecular Assembly of Peptide Nanofibers” (opens in new tab), Journal of the American Chemical Society, vol. 147, pp. 24699-24707, 2025.
- Shrestha, R., Guan, Z., “Tunable Polyethylene-polypropylene Blends via Compatibilization through Nitrene Insertion-Enabled Dynamic Covalent Crosslinking” (opens in new tab), Polymer Chemistry, vol. 16, pp. 1807-1812, 2025.
- Wei H., Pascual-Herrero H., Selmani S., Marroquin S., Reginato G.D., Guan Z., Ragan R., “Corrigendum to “Nanoantennas report dissipative assembly in oscillatory electric fields” [J. Colloid Interface Sci. 666 (2024) 629–638, (S0021979724007124), (10.1016/j.jcis.2024.03.203)]” (opens in new tab), Journal of Colloid and Interface Science, vol. 678, pp. 970, 2025.
- Guan, Z., “Sustainable polymers that stick inside and out” (opens in new tab), Science, vol. 385, pp. 829-830, 2024.
- Castro, J., Westworth, X., Shrestha, R., Yokoyama, K., Guan, Z., “Efficient and Robust Dynamic Crosslinking for Compatibilizing Immiscible Mixed Plastics through In Situ Generated Singlet Nitrenes” (opens in new tab), Advanced Materials, vol. 36, pp. 2406203, 2024.
- Yokoyama, K., Guan, Z., “A Vitrimer Acts as a Compatibilizer for Polyethylene and Polypropylene Blends” (opens in new tab), Angewandte Chemie International Edition, vol. 63, 2024.
- Gibson, W., Mulvey, J. T., Das, S., Selmani, S., Merham, J. V., Rakowski, A. M., Schwartz, E., Hochbaum, A., Guan, Z., Green, J. R., Patterson, J. P., “Observing the Dynamics of an Electrochemically Driven Active Material with Liquid Electron Microscopy” (opens in new tab), ACS Nano, vol. 18, pp. 11898-11909, 2024.
- Wei, H., Pascual-Herrero, H., Selmani, S., Marroquin, S., Reginato, G. D., Guan, Z., Ragan, R., “Nanoantennas Report Dissipative Assembly in Oscillatory Electric Fields” (opens in new tab), Journal of Colloid and Interface Science, vol. 666, pp. 629-638, 2024.
- Song, Y. M., Selmani, S., Freites, J. F., Guan, Z., Tobias, D. J., “Multiscale Molecular Dynamics Simulations of an Active Self-Assembling Material” (opens in new tab), Journal of Physical Chemistry B, vol. 128, pp. 1266-1274, 2024.
- Hurst, P. J., Mulvey, J., Bone, A. R., Selmani, S., Hudson, R. F., Guan, Z., Green, J. R., Patterson, J. P., “CryoEM reveals the complex self-assembly of a chemically driven disulfide hydrogel” (opens in new tab), Chemical Science, vol. 15, pp. 1106-1116, 2024.
- Chen, C., Guan, Z., “Precise Control of Dissipative Self-assembly by Light and Electricity” (opens in new tab), Chemistry A European Journal, vol. 29, pp. e2023003, 2023.
- Barpuzary, D., Hurst, P. J., Patterson, J. P., Guan, Z., “Waste Free Fully Electrically Fueled Dissipative Self-assembly System” (opens in new tab), Journal of the American Chemical Society, vol. 145, pp. 3727-3735, 2023.
- Tretbar, C., Castro, J., Yokoyama, K., Guan, Z., “Fluoride-catalyzed Siloxane Exchange as a Robust Dynamic Chemistry for High-performance Vitrimers” (opens in new tab), Advanced Materials, vol. 35, pp. 2303280, 2023.
- Jo, H., Selmani, S., Guan, Z., Sim, S., “Sugar-fueled Dissipative Living Materials” (opens in new tab), Journal of the American Chemical Society, vol. 145, pp. 1811-1817, 2023.
- Hickey, J. C., Hurst, P. J., Patterson, J. P., Guan, Z., “Facile Synthesis of Multifunctional Bioreducible Polymers For mRNA Delivery” (opens in new tab), Chemistry A European Journal, vol. 29, 2022.
- Camacho-Fernandez, M. A., Ziller, J. W., Guan, Z., “Comparative Investigation of η6-Arene Tethered Ru(II) Complexes with Different Tethered Heteroatoms for Ethylene Polymerization Catalysis: Experimental and DFT Studies” (opens in new tab), Organometallics, vol. 144, pp. 7844-7851, 2022.
- Selmani, Serxho, Schwartz, Eric, Mulvey, Justin T., Wei, Hong, Grosvirt-Dramen, Adam, Gibson, Wyeth, Hochbaum, Allon I., Patterson, Joseph P., Ragan, Regina, Guan, Z., “Electrically Fueled Active Supramolecular Materials” (opens in new tab), Journal of the American Chemical Society, vol. 144, pp. 7844-7851, 2022.
- Fan, Z., Jan, S., Hickey, J. C., Davies, D. H., Felgner, J., Felgner, P. L., Guan, Z., “Multifunctional Dendronized Polypeptides for Controlled Adjuvanticity” (opens in new tab), Biomacromolecules, vol. 22, pp. 5074-5086, 2021.
Most Cited Publications
- Chen, Y.L., Kushner, A. M., Williams, G. A., Guan, Z., “Multiphase Design of Autonomic Self-Healing Thermoplastic Elastomers” (opens in new tab), Nature Chemistry, vol. 4, pp. 467-472, 2012.
- Cromwell, O., Chung, J., Guan, Z., “Malleable and Self-Healing Covalent Polymer Networks through Tunable Dynamic Boronic Ester Bonds” (opens in new tab), Journal of the American Chemical Society, vol. 137, pp. 6492-6495, 2015.
- Guan, Z., Cotts, P. M., McCord, E. F., McLain, S. J., “Chain Walking – A New Strategy to Control Polymer Topology” (opens in new tab), Science, vol. 283, pp. 2059, 1999.
- Mozhdehi, D., Ayala, S., Cromwell, O. R., Guan, Z., “Self-Healing Multiphase Polymers via Dynamic Metal-Ligand Interactions” (opens in new tab), Journal of the American Chemical Society, vol. 136, pp. 16128-16131, 2014.
- Lu, Y.-X., Tournilhac, F., Leibler, L., Guan, Z., “Making Insoluble Polymer Networks Malleable via Olefin Methathesis” (opens in new tab), Journal of the American Chemical Society, vol. 134, pp. 8424-8427, 2012.
- Lu, Y.-X., Guan, Z., “Olefin Metathesis for Effective Polymer Healing via Dynamic Exchange of Strong Carbon-Carbon Double Bonds” (opens in new tab), Journal of the American Chemical Society, vol. 134, pp. 14226-14231, 2012.
- Nishimura, Y., Chung, J., Guan, Z., “Silyl Ether as a Robust and Thermally Stable Dynamic Covalent Motif for Malleable Polymer Design” (opens in new tab), Journal of the American Chemical Society, vol. 139, pp. 14881-14884, 2017.
- Neal, J., Mozhdehi, Guan, Z., “Enhancing Mechanical Performance of a Covalent Self-Healing Material by Sacrificial Noncovalent Bonds” (opens in new tab), Journal of the American Chemical Society, vol. 137, pp. 4846-4850, 2015.
- Jia, X., Qin, C., Friedberger, T., Guan, Z., Huang, Z., “Efficient and Selective Degradation of Polyethylenes into Liquid Fuels and Waxes under Mild Conditions” (opens in new tab), Science Advances, vol. 2, no. 6, 2016.
- Ogden, W., Guan, Z., “Recyclable, Strong, and Highly Malleable Thermosets Based on Boroxine Networks” (opens in new tab), Journal of the American Chemical Society, vol. 140, pp. 6217-6220, 2018.
Contact Information
Email: zguan@uci.edu
Phone: (949) 824-5172, 9173
Address: 1123 Reines Hall
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Last updated on 5/19/2026.